Heritability of insidious uveitis in Appaloosa horses.
ERU
autoimmune
equine
genetics
inflammation
ocular
Journal
Animal genetics
ISSN: 1365-2052
Titre abrégé: Anim Genet
Pays: England
ID NLM: 8605704
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
revised:
09
09
2022
received:
18
03
2022
accepted:
20
09
2022
pubmed:
11
10
2022
medline:
8
11
2022
entrez:
10
10
2022
Statut:
ppublish
Résumé
Equine recurrent uveitis (ERU) is a blinding ocular disorder among horses, and the Appaloosa horse breed is disproportionally affected by a chronic form of this intraocular inflammatory disease known as insidious uveitis. Strong breed predisposition and previous investigations suggest that there is a genetic component to the pathology of insidious uveitis among Appaloosa horses; however, no estimates of the heritability of the disease have previously been determined. This study aimed to characterize the genetic underpinning of the disease by estimating the heritability for insidious uveitis among Appaloosas. After combining two genotyping array datasets from the Illumina Equine SNP70 BeadChip and the Axiom Equine 670 K Genotyping Array, heritability was estimated for 59 affected and 83 unaffected horses using both restricted maximum likelihood (REML) and phenotype correlation - genotype correlation solvers from the linkage disequilibrium adjusted kinship software. Based on previous research, age and sex were used as covariates, and the locus responsible for the characteristic Appaloosa coat pattern (LP), previously associated with ERU risk, was included as a fixed effect ('top predictor'). Using prevalence values from 0.05 to 0.42, the heritability estimate for insidious uveitis ranged from 0.95 (SE = 0.14) to 1.74 (SE = 0.25) with LP contributing 0.16-0.33 to the estimate. This study suggests that insidious uveitis is highly heritable (REML 95% CI, h
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
872-877Subventions
Organisme : Center for Equine Health
Organisme : Morris Animal Foundation
ID : D16EQ-028
Organisme : Townsend Equine Health Research Fund (TEHRF)
Informations de copyright
© 2022 Stichting International Foundation for Animal Genetics.
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