Extranodal localization of non-Hodgkin's lymphoma in systemic sclerosis: A diagnostic challenge and review of the literature.
B-cell lymphoma
Systemic sclerosis
hematological malignancies
splenic marginal zone lymphoma
Journal
Journal of scleroderma and related disorders
ISSN: 2397-1991
Titre abrégé: J Scleroderma Relat Disord
Pays: England
ID NLM: 101685427
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
16
02
2022
accepted:
01
03
2022
entrez:
10
10
2022
pubmed:
11
10
2022
medline:
11
10
2022
Statut:
ppublish
Résumé
Systemic sclerosis is associated with an increased incidence of malignancies, in particular solid neoplasms. Hematological cancers have been also observed in autoimmune diseases, though rarely present with lung involvement. The latter may be misdiagnosed in systemic sclerosis patients, due to the frequent concomitant interstitial lung disease. Here, we present the case of a 63-year-old man affected by systemic sclerosis presenting with an atypical lung imaging and splenomegaly, who was diagnosed with splenic marginal zone lymphoma, thus raising the suspicion of lung secondarism. We discuss the diagnostic challenge of differential diagnosis in interstitial lung presentation and briefly review the available literature on this topic. Several reports have demonstrated an increased risk of malignancy in patients with systemic sclerosis. Still, the lack of concretely defined guidelines for systemic sclerosis, along with systemic sclerosis multifaceted organ involvement at presentation, may challenge diagnosis and management. Here, we remark the importance of clinical work-up and a multidisciplinary approach in systemic sclerosis, to early detect and treat concomitant hematological malignancies, especially during the first years of the disease.
Sections du résumé
Background
UNASSIGNED
Systemic sclerosis is associated with an increased incidence of malignancies, in particular solid neoplasms. Hematological cancers have been also observed in autoimmune diseases, though rarely present with lung involvement. The latter may be misdiagnosed in systemic sclerosis patients, due to the frequent concomitant interstitial lung disease.
Case description
UNASSIGNED
Here, we present the case of a 63-year-old man affected by systemic sclerosis presenting with an atypical lung imaging and splenomegaly, who was diagnosed with splenic marginal zone lymphoma, thus raising the suspicion of lung secondarism. We discuss the diagnostic challenge of differential diagnosis in interstitial lung presentation and briefly review the available literature on this topic.
Conclusion
UNASSIGNED
Several reports have demonstrated an increased risk of malignancy in patients with systemic sclerosis. Still, the lack of concretely defined guidelines for systemic sclerosis, along with systemic sclerosis multifaceted organ involvement at presentation, may challenge diagnosis and management. Here, we remark the importance of clinical work-up and a multidisciplinary approach in systemic sclerosis, to early detect and treat concomitant hematological malignancies, especially during the first years of the disease.
Identifiants
pubmed: 36211199
doi: 10.1177/23971983221088459
pii: 10.1177_23971983221088459
pmc: PMC9537711
doi:
Types de publication
Case Reports
Langues
eng
Pagination
NP1-NP6Informations de copyright
© The Author(s) 2022.
Déclaration de conflit d'intérêts
The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Références
Sci Rep. 2019 Jun 17;9(1):8657
pubmed: 31209274
Rheumatology (Oxford). 2021 Feb 1;60(2):557-567
pubmed: 33164098
Front Immunol. 2019 Jan 10;9:3112
pubmed: 30687318
J Clin Exp Pathol. 2015 Feb;5(1):
pubmed: 26457231
Leukemia. 2008 Mar;22(3):487-95
pubmed: 18094718
Chest. 2008 Feb;133(2):433-40
pubmed: 18071012
Cancers (Basel). 2021 Jan 22;13(3):
pubmed: 33499258
Case Rep Rheumatol. 2017;2017:6230138
pubmed: 28546881
Oncology. 2003;64(4):336-40
pubmed: 12759529
Dermatol Ther. 2019 Sep;32(5):e13041
pubmed: 31361930
Drugs. 2010 Jul 30;70(11):1445-76
pubmed: 20614951
Int J Hematol. 2015 Jan;101(1):46-51
pubmed: 25378228
Histopathology. 2018 Mar;72(4):704-706
pubmed: 28945277
Br J Radiol. 2012 Jul;85(1015):848-64
pubmed: 22745203
Lupus. 2020 Mar;29(3):225-235
pubmed: 31933408
Lancet. 2017 Oct 7;390(10103):1685-1699
pubmed: 28413064
Br J Dermatol. 2010 Oct;163(4):800-6
pubmed: 20854403
J Thorac Dis. 2018 Nov;10(11):6040-6049
pubmed: 30622775