Primary heart involvement in systemic sclerosis, from conventional to innovative targeted therapeutic strategies.
Systemic sclerosis
fibrosis
inflammation
primary heart involvement
therapy
Journal
Journal of scleroderma and related disorders
ISSN: 2397-1991
Titre abrégé: J Scleroderma Relat Disord
Pays: England
ID NLM: 101685427
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
03
01
2022
accepted:
08
02
2022
entrez:
10
10
2022
pubmed:
11
10
2022
medline:
11
10
2022
Statut:
ppublish
Résumé
Primary heart involvement is frequent in systemic sclerosis, even though often sub-clinical, and includes cardiac abnormalities that are predominantly attributable to systemic sclerosis rather than other causes and/or complications. A timely diagnosis is crucial to promptly start the appropriate therapy and to prevent the potential life-threatening early and late complications. There is little evidence on how to best manage systemic sclerosis-primary heart involvement as no specific treatment recommendations for heart disease are available, and a shared treatment approach is still lacking. The objective of this review is to summarize the state of the art of current literature and the overall management strategies and therapeutic approaches for systemic sclerosis-primary heart involvement. Novel insights into pathogenic mechanisms of systemic sclerosis-primary heart involvement are presented to facilitate the comprehension of therapeutic targets and novel treatment strategies.
Identifiants
pubmed: 36211207
doi: 10.1177/23971983221083772
pii: 10.1177_23971983221083772
pmc: PMC9537702
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
179-188Informations de copyright
© The Author(s) 2022.
Déclaration de conflit d'intérêts
The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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