The ventral striatum contributes to the activity of the motor cortex and motor outputs in monkeys.
basal gangalia
effort
electrocorticogram (ECoG)
motor control
non-human primate
Journal
Frontiers in systems neuroscience
ISSN: 1662-5137
Titre abrégé: Front Syst Neurosci
Pays: Switzerland
ID NLM: 101477946
Informations de publication
Date de publication:
2022
2022
Historique:
received:
27
06
2022
accepted:
10
08
2022
entrez:
10
10
2022
pubmed:
11
10
2022
medline:
11
10
2022
Statut:
epublish
Résumé
The ventral striatum (VSt) is thought to be involved in the vigor of motivated behavior and is suggested to be a limbic-motor interface between limbic areas involved in motivational processes and neural circuits regulating behavioral outputs. However, there is little direct evidence demonstrating the involvement of the VSt in motor control for motivated behaviors. To clarify the functional role of the VSt in motor control, we investigated the effect of reversible pharmacological inactivation of the VSt on the oscillatory activity of the sensorimotor cortices and motor outputs in two macaque monkeys. VSt inactivation reduced movement-related activities of the primary motor cortex and premotor area at 15-120 Hz and increased those at 5-7 Hz. These changes were accompanied by reduced torque outputs but had no effect on the correct performance rate. The present study provides direct evidence that the VSt regulates activities of the motor cortices and motor output.
Identifiants
pubmed: 36211590
doi: 10.3389/fnsys.2022.979272
pmc: PMC9540202
doi:
Types de publication
Journal Article
Langues
eng
Pagination
979272Informations de copyright
Copyright © 2022 Suzuki and Nishimura.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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