Plasma glycocholic acid and linoleic acid identified as potential mediators of mitochondrial bioenergetics in Alzheimer's dementia.
Alzheimer’s disease
bioenergetics
glycocholic acid
linoleic acid
metabolomics
mitochondria
neurons
plasma
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2022
2022
Historique:
received:
26
05
2022
accepted:
18
08
2022
entrez:
10
10
2022
pubmed:
11
10
2022
medline:
11
10
2022
Statut:
epublish
Résumé
Mitochondrial bioenergetic alterations occur in the brain and peripheral cells of patients with Alzheimer's disease (AD). This study focuses on plasma circulating factors, namely lipids, as mediators of systemic bioenergetic differences in participants with normal cognition (NC), mild cognitive impairment (MCI), and dementia due to probable AD (DEM). We examined bioenergetic differences across cognitive groups by measuring the mitochondrial respiration of peripheral blood mononuclear cells (PBMCs) from 37 participants (12 NC, 12 MCI, 13 DEM). PBMC bioenergetics were lower in the DEM group compared to the NC group. To determine whether circulating factors can mediate bioenergetic differences according to cognitive status, we exposed naïve neuronal Neuro-2a (N2a) cells to plasma from each participant
Identifiants
pubmed: 36212044
doi: 10.3389/fnagi.2022.954090
pmc: PMC9540364
doi:
Types de publication
Journal Article
Langues
eng
Pagination
954090Subventions
Organisme : NIA NIH HHS
ID : P30 AG072947
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054523
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG061805
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM127261
Pays : United States
Informations de copyright
Copyright © 2022 Amick, Mahapatra, Gao, Dewitt, Craft, Jain and Molina.
Déclaration de conflit d'intérêts
Author MJ was the founder of Sapient Bioanalytics, San Diego, CA. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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