Comparison between conduction system pacing and cardiac resynchronization therapy in right bundle branch block patients.
cardiac resynchronization therapy
conduction system pacing
dyssynchrony
heart failure
his bundle pacing
left bundle pacing
right bundle branch block
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
04
08
2022
accepted:
29
08
2022
entrez:
10
10
2022
pubmed:
11
10
2022
medline:
11
10
2022
Statut:
epublish
Résumé
A significant number of right bundle branch block (RBBB) patients receive cardiac resynchronization therapy (CRT), despite lack of evidence for benefit in this patient group. His bundle (HBP) and left bundle pacing (LBP) are novel CRT delivery methods, but their effect on RBBB remains understudied. We aim to compare pacing-induced electrical synchrony during conventional CRT, HBP, and LBP in RBBB patients with different conduction disturbances, and to investigate whether alternative ways of delivering LBP improve response to pacing. We simulated ventricular activation on twenty-four four-chamber heart geometries each including a His-Purkinje system with proximal right bundle branch block (RBBB). We simulated RBBB combined with left anterior and posterior fascicular blocks (LAFB and LPFB). Additionally, RBBB was simulated in the presence of slow conduction velocity (CV) in the myocardium, left ventricular (LV) or right ventricular (RV) His-Purkinje system, and whole His-Purkinje system. Electrical synchrony was measured by the shortest interval to activate 90% of the ventricles (BIVAT-90). Compared to baseline, HBP significantly improved activation times for RBBB alone (BIVAT-90: 66.9 ± 5.5 ms vs. 42.6 ± 3.8 ms,
Identifiants
pubmed: 36213223
doi: 10.3389/fphys.2022.1011566
pii: 1011566
pmc: PMC9532840
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1011566Informations de copyright
Copyright © 2022 Strocchi, Gillette, Neic, Elliott, Wijesuriya, Mehta, Vigmond, Plank, Rinaldi and Niederer.
Déclaration de conflit d'intérêts
Author AN is employed by NumeriCor GmbH, Graz, Austria. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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