Developmental or adult-onset deletion of neurotensin receptor-1 from dopamine neurons differentially reduces body weight.
energy balance
feeding
locomotor activity
obesity
ventral tegmental area (VTA)
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2022
2022
Historique:
received:
11
02
2022
accepted:
17
08
2022
entrez:
10
10
2022
pubmed:
11
10
2022
medline:
11
10
2022
Statut:
epublish
Résumé
Central neurotensin signaling via neurotensin receptor-1 (NtsR1) modulates various aspects of physiology, including suppressing feeding and promoting locomotor activity that can support weight loss. However, it remains unclear when and where NtsR1 expression contributes to control of body weight vs. other effects. We previously showed that activating ventral tegmental area (VTA) dopamine (DA) neurons that express NtsR1 promotes weight loss. We therefore hypothesized that deleting NtsR1 from DA neurons would promote weight gain by increasing food intake and decreasing physical activity. In contrast, developmental deletion of NtsR1 from DA neurons (by crossing
Identifiants
pubmed: 36213756
doi: 10.3389/fnins.2022.874316
pmc: PMC9537700
doi:
Types de publication
Journal Article
Langues
eng
Pagination
874316Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM142521
Pays : United States
Informations de copyright
Copyright © 2022 Perez-Bonilla, Ramirez-Virella, Menon, Troyano-Rodriguez, Arriaga, Makela, Bugescu, Beckstead and Leinninger.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Neurosci. 2020 Jan 15;40(3):632-647
pubmed: 31744862
Nat Neurosci. 2017 Mar;20(3):449-458
pubmed: 28135243
J Pharmacol Exp Ther. 2002 Jan;300(1):305-13
pubmed: 11752130
eNeuro. 2018 Feb 12;5(1):
pubmed: 29464190
Brain Res. 2006 Apr 12;1082(1):98-101
pubmed: 16516172
J Vis Exp. 2012 May 03;(63):e3754
pubmed: 22588164
Eur J Pharmacol. 2008 Sep 11;592(1-3):109-15
pubmed: 18652823
Cell Rep. 2017 Dec 12;21(11):3116-3128
pubmed: 29241540
Neuropharmacology. 2020 May 1;167:108005
pubmed: 32057800
Neuroscience. 1986 Jul;18(3):659-69
pubmed: 2427971
Neurosci Lett. 1986 Jul 24;68(2):239-44
pubmed: 3748452
N Engl J Med. 2017 Jul 6;377(1):80-81
pubmed: 28604226
Cell Metab. 2013 Jul 2;18(1):21-8
pubmed: 23823475
Life Sci. 1986 Jun 30;38(26):2383-8
pubmed: 3459947
Neuropsychopharmacology. 2016 Feb;41(3):811-21
pubmed: 26171719
J Neurosci. 1994 May;14(5 Pt 1):2687-96
pubmed: 7514209
J Neurosci. 2013 Aug 21;33(34):13861-72
pubmed: 23966705
Recent Prog Horm Res. 1998;53:163-99
pubmed: 9769708
Neuroscience. 1988 Apr;25(1):307-17
pubmed: 2839800
Neuropsychopharmacology. 2021 Feb;46(3):491-499
pubmed: 33318634
Cell. 1995 Dec 29;83(7):1197-209
pubmed: 8548806
Behav Brain Res. 2008 Dec 1;194(1):66-71
pubmed: 18639588
N Engl J Med. 2017 Jul 6;377(1):13-27
pubmed: 28604169
Int J Neuropsychopharmacol. 2018 Nov 1;21(11):1049-1065
pubmed: 30239762
Neuropharmacology. 2010 Jun;58(8):1199-205
pubmed: 20211191
Lancet. 2005 Oct 1;366(9492):1197-209
pubmed: 16198769
Eur J Neurosci. 2019 Mar;49(6):784-793
pubmed: 29405480
Front Neuroendocrinol. 2010 Jan;31(1):104-12
pubmed: 19836414
Neuroscience. 1987 Oct;23(1):189-98
pubmed: 3683860
Acta Histochem. 2014 Mar;116(2):382-9
pubmed: 24144485
J Neurosci. 1995 Jul;15(7 Pt 2):5169-78
pubmed: 7623143
Neuropharmacology. 2019 Aug;154:13-21
pubmed: 30266601
Am J Physiol Regul Integr Comp Physiol. 2019 Jan 1;316(1):R6-R12
pubmed: 30406672
J Neurosci. 1999 Oct 1;19(19):RC29
pubmed: 10493774
J Vis Exp. 2015 Feb 06;(96):e52434
pubmed: 25742564
Neuron. 2006 Sep 21;51(6):811-22
pubmed: 16982425
Int J Obes (Lond). 2013 Mar;37(3):382-9
pubmed: 22508336
Neuropharmacology. 2021 Sep 1;195:108639
pubmed: 34116109
Brain Res. 2002 Oct 25;953(1-2):63-72
pubmed: 12384239
Neuron. 1990 Jun;4(6):847-54
pubmed: 1694443
Diabetes Care. 2008 Feb;31 Suppl 2:S269-77
pubmed: 18227496
J Physiol. 1994 Jan 1;474(1):119-29
pubmed: 8014889
J Neurosci. 2015 Oct 07;35(40):13773-83
pubmed: 26446228
Neuroscience. 1987 Aug;22(2):525-36
pubmed: 3313097
Indian J Med Res. 2020 Jan;151(1):11-21
pubmed: 32134010
Brain Res Dev Brain Res. 1999 Mar 12;113(1-2):115-31
pubmed: 10064881
Mol Metab. 2013 Aug 07;2(4):423-34
pubmed: 24327958
Cell Rep. 2017 Aug 22;20(8):1881-1892
pubmed: 28834751
Brain Res Mol Brain Res. 1992 Oct;15(3-4):332-8
pubmed: 1331689
Physiol Behav. 1988;44(4-5):599-606
pubmed: 3237847
Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):900-916
pubmed: 29288794