Isolation of an Extensively Drug-Resistant Pseudomonas aeruginosa
NDM-1
ST654
VIM-80
carbapenem-resistant Pseudomonas aeruginosa
high-risk clone
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
26 10 2022
26 10 2022
Historique:
pubmed:
11
10
2022
medline:
29
10
2022
entrez:
10
10
2022
Statut:
ppublish
Résumé
The aim of this study was to investigate the genomic features of an extensively drug-resistant (XDR) Pseudomonas aeruginosa isolate (P-469) emerging in Chile. Antibiotic susceptibility was determined by disk diffusion and "colistin agar" test. Whole-genome sequencing (WGS) was performed by the Illumina NextSeq 2000 platform, and epidemiologically and clinically relevant data (i.e., sequence-type, serotype, mobile genetic elements, virulome, resistome, plasmidome, prophages, and CRISPR-Cas systems) were retrieved using multiple bioinformatic tools. The P-469 strain displayed an XDR profile, remaining susceptible to colistin. Genomic analysis revealed that this isolate belonged to the "high-risk" clone ST654 (CC654), serotype O4, and genotype
Identifiants
pubmed: 36214677
doi: 10.1128/spectrum.01439-22
pmc: PMC9604125
doi:
Substances chimiques
beta-lactamase NDM-1
EC 3.5.2.6
Colistin
Z67X93HJG1
Agar
9002-18-0
Anti-Bacterial Agents
0
beta-Lactamases
EC 3.5.2.6
Types de publication
Letter
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0143922Références
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