The association of obesity with euploidy rates in women undergoing in vitro fertilization with preimplantation genetic testing.
Body mass index
Euploidy rate
In vitro fertilization
Preimplantation genetic testing
Journal
Journal of assisted reproduction and genetics
ISSN: 1573-7330
Titre abrégé: J Assist Reprod Genet
Pays: Netherlands
ID NLM: 9206495
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
15
06
2022
accepted:
17
09
2022
pubmed:
11
10
2022
medline:
25
2
2023
entrez:
10
10
2022
Statut:
ppublish
Résumé
The purpose of this study was to determine the impact of body mass index (BMI) on euploidy rates for in vitro fertilization (IVF) cycles with preimplantation genetic testing (PGT) utilizing primarily next-generation sequencing (NGS). This retrospective cohort study included women aged ≤ 45 years who underwent IVF/PGT between September 2013 and September 2020 at a single university-affiliated fertility center. The primary outcome was euploidy rate. Secondary outcomes included peak serum estradiol (E2), number of oocytes retrieved, oocyte maturation rate, high-quality blastulation rate, clinical loss rate (CLR), clinical pregnancy rate (CPR), and ongoing pregnancy/live birth rate (OPR/LBR). The study included 1335 IVF cycles that were stratified according to BMI (normal, n = 648; overweight, n = 377; obese, n = 310). The obese group was significantly older with significantly lower baseline FSH, peak E2, high-quality blastulation rate, and number of embryos biopsied than the normal group. Overall euploidy rates were not significantly different between BMI groups (normal 36.4% ± 1.3; overweight 37.3% ± 1.8; obese 32.3% ± 1.8; p = 0.11), which persisted after controlling for covariates (p = 0.82) and after stratification of euploidy rate by age group and by number of oocytes retrieved per age group. There were no significant differences in CLR, CPR, and OPR/LBR across BMI groups. Despite a lower high quality blastulation rate with obesity, there is not a significant difference in euploidy rates across BMI groups in women undergoing IVF/PGT.
Identifiants
pubmed: 36214982
doi: 10.1007/s10815-022-02624-8
pii: 10.1007/s10815-022-02624-8
pmc: PMC9723054
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2521-2528Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Fertil Steril. 2017 Apr;107(4):840-847
pubmed: 28292619
Pediatrics. 2003 May;111(5 Pt 2):1152-8
pubmed: 12728129
Am J Obstet Gynecol. 2004 Apr;190(4):1091-7
pubmed: 15118648
Obstet Gynecol. 2011 Jul;118(1):63-70
pubmed: 21691164
Reprod Health. 2018 Feb 27;15(1):34
pubmed: 29486787
Fertil Steril. 2016 Feb;105(2):364-8
pubmed: 26523329
Fertil Steril. 2021 Jun;115(6):1495-1502
pubmed: 33267960
Fertil Steril. 2016 Mar;105(3):703-706.e2
pubmed: 26690012
Endocr Rev. 2018 Apr 1;39(2):79-132
pubmed: 29518206
Menopause. 2010 Jul;17(4):718-26
pubmed: 20216473
Curr Opin Obstet Gynecol. 1999 Jun;11(3):307-11
pubmed: 10369209
PLoS One. 2012;7(11):e49217
pubmed: 23152876
Fertil Steril. 2015 Mar;103(3):744-8
pubmed: 25576217
Biol Reprod. 2019 Dec 24;101(6):1083-1090
pubmed: 30721942
J Clin Med. 2020 Mar 05;9(3):
pubmed: 32151008
Reprod Biomed Online. 2011 Oct;23(4):490-9
pubmed: 21856228
J Assist Reprod Genet. 2020 Mar;37(3):611-617
pubmed: 31897845
Hum Fertil (Camb). 2015 Sep;18(3):215-9
pubmed: 25895556
Fertil Steril. 2013 May;99(6):1654-62
pubmed: 23394781
J Assist Reprod Genet. 2011 Jun;28(6):517-24
pubmed: 21625966
Hum Reprod. 2008 Feb;23(2):324-8
pubmed: 18077317
Hum Reprod. 2007 Feb;22(2):414-20
pubmed: 17095518
Hum Reprod Update. 2003 Sep-Oct;9(5):429-49
pubmed: 14640376
Fertil Steril. 2010 Feb;93(2):447-54
pubmed: 19171335
Reprod Biomed Online. 2007 Nov;15(5):532-8
pubmed: 18044034
Hum Reprod. 2011 Jan;26(1):245-52
pubmed: 21071489
Hum Reprod Update. 2019 Jul 1;25(4):439-451
pubmed: 30941397
Fertil Steril. 2008 Sep;90(3):714-26
pubmed: 18068166
Metabolism. 1997 Jan;46(1):5-9
pubmed: 9005961
Fertil Steril. 2012 Jul;98(1):102-8
pubmed: 22584023
J Assist Reprod Genet. 2000 Nov;17(10):547-52
pubmed: 11209534
J Assist Reprod Genet. 2018 Apr;35(4):669-675
pubmed: 29297113
Hum Reprod. 2011 Oct;26(10):2642-50
pubmed: 21813669
Hum Reprod Update. 2007 Sep-Oct;13(5):433-44
pubmed: 17584821
Fertil Steril. 2022 Apr;117(4):783-789
pubmed: 35105446
Fertil Steril. 2013 Oct;100(4):1050-8
pubmed: 23830106
Obstet Gynecol. 2004 Feb;103(2):219-24
pubmed: 14754687
Fertil Steril. 2021 Aug;116(2):444-452
pubmed: 33581854
Am J Obstet Gynecol. 2020 Apr;222(4):363.e1-363.e7
pubmed: 31589862
Front Endocrinol (Lausanne). 2019 Aug 02;10:516
pubmed: 31428050
Pharmacoeconomics. 2015 Jul;33(7):673-89
pubmed: 25471927