Prevention of Oxidative Damage in Spinal Cord Ischemia Upon Aortic Surgery: First-In-Human Results of Shock Wave Therapy Prove Safety and Feasibility.
Humans
Mice
Animals
Aged
Toll-Like Receptor 3
/ metabolism
Extracorporeal Shockwave Therapy
NF-E2-Related Factor 2
Zebrafish
Feasibility Studies
Reactive Oxygen Species
Quality of Life
Spinal Cord Ischemia
/ etiology
Spinal Cord Injuries
/ therapy
Spinal Cord
/ metabolism
Oxidative Stress
Ischemia
Aortic Dissection
/ pathology
Toll‐Like receptor 3
shock wave therapy
spinal cord ischemia
spinal cord regeneration
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
18 10 2022
18 10 2022
Historique:
pubmed:
11
10
2022
medline:
21
10
2022
entrez:
10
10
2022
Statut:
ppublish
Résumé
Background Spinal cord ischemia (SCI) remains a devastating complication after aortic dissection or repair. A primary hypoxic damage is followed by a secondary damage resulting in further cellular loss via apoptosis. Affected patients have a poor prognosis and limited therapeutic options. Shock wave therapy (SWT) improves functional outcome, neuronal degeneration and survival in murine spinal cord injury. In this first-in-human study we treated 5 patients with spinal cord ischemia with SWT aiming to prove safety and feasibility. Methods and Results Human neurons were subjected to ischemic injury with subsequent SWT. Reactive oxygen species and cellular apoptosis were quantified using flow cytometry. Signaling of the antioxidative transcription factor NRF2 (nuclear factor erythroid 2-related factor 2) and immune receptor Toll-like receptor 3 (TLR3) were analyzed. To assess whether SWT act via a conserved mechanism, transgenic
Identifiants
pubmed: 36216458
doi: 10.1161/JAHA.122.026076
pmc: PMC9673656
doi:
Substances chimiques
Toll-Like Receptor 3
0
NF-E2-Related Factor 2
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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