The UHRF protein family in epigenetics, development, and carcinogenesis.
DNA methylation
DNA repair
UHRF1
UHRF2
cancer
development
Journal
Proceedings of the Japan Academy. Series B, Physical and biological sciences
ISSN: 1349-2896
Titre abrégé: Proc Jpn Acad Ser B Phys Biol Sci
Pays: Japan
ID NLM: 9318162
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
10
10
2022
pubmed:
11
10
2022
medline:
13
10
2022
Statut:
ppublish
Résumé
The UHRF protein family consists of multidomain regulatory proteins that sense modification status of DNA and/or proteins and catalyze the ubiquitylation of target proteins. Through their functional domains, they interact with other molecules and serve as a hub for regulatory networks of several important biological processes, including maintenance of DNA methylation and DNA damage repair. The UHRF family is conserved in vertebrates and plants but is missing from fungi and many nonvertebrate animals. Mammals commonly have UHRF1 and UHRF2, but, despite their high structural similarity, the two paralogues appear to have distinct functions. Furthermore, UHRF1 and UHRF2 show different expression patterns and different outcomes in gene knockout experiments. In this review, we summarize the current knowledge on the molecular function of the UHRF family in various biological pathways and discuss their roles in epigenetics, development, gametogenesis, and carcinogenesis, with a focus on the mammalian UHRF proteins.
Identifiants
pubmed: 36216533
doi: 10.2183/pjab.98.021
pmc: PMC9614205
doi:
Substances chimiques
CCAAT-Enhancer-Binding Proteins
0
DNA
9007-49-2
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
401-415Références
Structure. 2019 Mar 5;27(3):485-496.e7
pubmed: 30639225
PLoS Genet. 2018 Oct 18;14(10):e1007643
pubmed: 30335751
FEBS J. 2017 Oct;284(20):3455-3469
pubmed: 28834260
J Cell Biol. 2002 Jun 10;157(6):909-14
pubmed: 12058012
PLoS Genet. 2021 May 28;17(5):e1009570
pubmed: 34048432
J Mol Biol. 2017 Dec 8;429(24):3814-3824
pubmed: 29055779
Mol Med Rep. 2016 Jan;13(1):315-20
pubmed: 26548607
Oncol Rep. 2018 Jun;39(6):2553-2562
pubmed: 29620240
Oncol Rep. 2014 Apr;31(4):1802-10
pubmed: 24573556
PLoS One. 2011;6(6):e21306
pubmed: 21731699
Nature. 2008 Oct 9;455(7214):818-21
pubmed: 18772891
Oncogene. 2004 Oct 7;23(46):7601-10
pubmed: 15361834
Cell Prolif. 1995 Dec;28(12):645-57
pubmed: 8634372
Cancer Cell. 2019 Apr 15;35(4):633-648.e7
pubmed: 30956060
Nature. 2007 Dec 6;450(7171):908-12
pubmed: 17994007
Asian Pac J Cancer Prev. 2012;13(10):5137-42
pubmed: 23244124
Mol Cell. 2017 Aug 17;67(4):550-565.e5
pubmed: 28803780
Sci Rep. 2022 Jan 24;12(1):1279
pubmed: 35075228
Onco Targets Ther. 2017 Dec 11;10:5863-5872
pubmed: 29270024
Nucleic Acids Res. 2018 Apr 6;46(6):3218-3231
pubmed: 29471350
Nucleic Acids Res. 2019 Jan 10;47(1):184-196
pubmed: 30357346
FEBS Lett. 2003 Nov 6;554(1-2):67-72
pubmed: 14596916
Oncogene. 2003 Apr 10;22(14):2172-85
pubmed: 12687019
Mol Cell Biol. 2008 Jan;28(2):705-17
pubmed: 17967883
Genome Biol. 2009;10(11):R130
pubmed: 19919682
Genome Biol. 2015 Sep 25;16:209
pubmed: 26408185
Biochem Biophys Res Commun. 2002 Aug 23;296(3):530-6
pubmed: 12176013
Nat Genet. 2005 Aug;37(8):853-62
pubmed: 16007088
J Cell Biochem. 2011 Feb;112(2):439-44
pubmed: 21268065
Cancer Cell. 2014 Feb 10;25(2):196-209
pubmed: 24486181
Proteins. 2022 Mar;90(3):835-847
pubmed: 34766381
FASEB J. 2019 Jul;33(7):8294-8305
pubmed: 30995416
Cell Rep. 2015 Mar 31;10(12):1947-56
pubmed: 25801034
Nature. 2004 Jun 24;429(6994):900-3
pubmed: 15215868
Development. 2021 May 15;148(10):
pubmed: 33998651
Sci Rep. 2017 Dec;7(1):55
pubmed: 28246399
Mol Cell. 2011 Nov 4;44(3):361-72
pubmed: 22055183
Mol Cell. 2017 Oct 19;68(2):350-360.e7
pubmed: 29053958
J Cancer. 2018 Jul 30;9(17):2994-3005
pubmed: 30210621
Genes Cells. 2021 Jun;26(6):349-359
pubmed: 33960584
Biochem Biophys Res Commun. 2013 Apr 19;433(4):415-9
pubmed: 23537643
Development. 2013 Jul;140(14):2892-903
pubmed: 23760957
Sci Rep. 2016 Nov 25;6:37490
pubmed: 27886214
J Cell Physiol. 2019 Nov;234(11):19875-19885
pubmed: 30989656
Genes Environ. 2016 May 01;38:9
pubmed: 27350828
Sci Rep. 2020 Oct 20;10(1):17865
pubmed: 33082427
Nat Commun. 2015 Jul 28;6:7870
pubmed: 26216346
PLoS Genet. 2008 Aug 15;4(8):e1000156
pubmed: 18704160
Int J Radiat Biol. 2011 Mar;87(3):263-73
pubmed: 21067293
Cancer Lett. 2012 Jan 28;314(2):223-31
pubmed: 22018986
Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E876-E885
pubmed: 29339483
Hum Mol Genet. 2018 Jul 15;27(14):2409-2424
pubmed: 29659838
Cell. 2013 Feb 28;152(5):1146-59
pubmed: 23434322
Cell Cycle. 2011 Oct 1;10(19):3284-99
pubmed: 21952639
Front Pharmacol. 2021 Feb 08;11:629266
pubmed: 33628188
PLoS Genet. 2012 Jan;8(1):e1002440
pubmed: 22242016
Nat Rev Genet. 2008 Feb;9(2):129-40
pubmed: 18197165
Cancer Med. 2019 Oct;8(14):6335-6343
pubmed: 31487123
Biochem Biophys Res Commun. 2013 Nov 8;441(1):65-70
pubmed: 24134842
Nature. 2013 Oct 10;502(7470):249-53
pubmed: 24013172
Sci Signal. 2010 Nov 02;3(146):ra80
pubmed: 21045206
Mol Plant. 2014 Sep;7(9):1470-1485
pubmed: 25009302
Cell Rep. 2015 Mar 31;10(12):1957-66
pubmed: 25818288
Oncology. 2018;95(3):179-187
pubmed: 29909415
Biochem Biophys Res Commun. 2004 Jun 25;319(2):464-8
pubmed: 15178429
Biol Reprod. 2013 May 23;88(5):125
pubmed: 23595900
J Thorac Oncol. 2021 Jan;16(1):89-103
pubmed: 32927122
Oncogene. 2012 Jan 19;31(3):333-41
pubmed: 21666724
Oncotarget. 2016 Nov 15;7(46):76047-76061
pubmed: 27738314
PLoS Genet. 2017 Oct 4;13(10):e1007042
pubmed: 28976982
Mol Cell. 2018 Nov 15;72(4):753-765.e6
pubmed: 30392931
J Biol Chem. 2010 Aug 20;285(34):26114-20
pubmed: 20547484
Mol Biol Rep. 2013 Sep;40(9):5225-35
pubmed: 23943380
Biochemistry. 2022 Mar 1;61(5):354-366
pubmed: 35143176
Cell. 2001 Mar 23;104(6):829-38
pubmed: 11290321
Front Cell Dev Biol. 2021 Sep 06;9:718624
pubmed: 34552929
J Biol Chem. 2002 Sep 13;277(37):34549-55
pubmed: 12084726
Cell Res. 2013 Mar;23(3):329-39
pubmed: 23399596
PLoS One. 2013 Dec 10;8(12):e82961
pubmed: 24340069
Mol Cell Biochem. 2022 Feb;477(2):537-547
pubmed: 34826027
Nucleic Acids Res. 2020 Dec 2;48(21):12116-12134
pubmed: 33170271
Curr Top Microbiol Immunol. 2006;301:179-201
pubmed: 16570848
Nucleic Acids Res. 2021 Jun 21;49(11):6053-6068
pubmed: 33939809
Transl Cancer Res. 2021 Jul;10(7):3527-3537
pubmed: 35116656
Genes (Basel). 2019 Jan 18;10(1):
pubmed: 30669400
Mamm Genome. 1998 Dec;9(12):1032-5
pubmed: 9880673
Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12950-5
pubmed: 22837395
Mol Cell. 2014 Jun 5;54(5):879-86
pubmed: 24813944
EMBO Rep. 2009 Nov;10(11):1259-64
pubmed: 19798101
Genes Dev. 2019 Jan 1;33(1-2):49-54
pubmed: 30602440
Nat Commun. 2020 Mar 6;11(1):1222
pubmed: 32144273
Nat Commun. 2016 Jan 05;7:10201
pubmed: 26727879
Nature. 2018 Dec;564(7734):136-140
pubmed: 30487604
Nat Genet. 2018 Apr;50(4):591-602
pubmed: 29610480
Nature. 2008 Oct 9;455(7214):826-9
pubmed: 18772888
Mol Oncol. 2022 Jun;16(11):2174-2194
pubmed: 34894177
Br J Cancer. 2003 Jul 7;89(1):120-7
pubmed: 12838312
Bioorg Med Chem. 2021 Dec 15;52:116500
pubmed: 34801826
Oncol Rep. 2012 Dec;28(6):1997-2002
pubmed: 23023523
Epigenetics. 2017 Jul 3;12(7):551-560
pubmed: 28402695
Genome Integr. 2010 Jun 08;1(1):7
pubmed: 20678257
Nat Genet. 2019 May;51(5):844-856
pubmed: 31040401
FEBS Lett. 2004 Jan 16;557(1-3):209-14
pubmed: 14741369
PLoS Genet. 2013 Apr;9(4):e1003439
pubmed: 23637617
Nature. 2013 Dec 19;504(7480):460-4
pubmed: 24291790
J Mol Biol. 2020 Jan 10;:
pubmed: 31931004
Genes Dev. 2008 Jun 15;22(12):1607-16
pubmed: 18559477
Genes Cells. 2004 Feb;9(2):131-42
pubmed: 15009091
Mol Cell. 2018 Nov 15;72(4):739-752.e9
pubmed: 30392929
Science. 2007 Sep 21;317(5845):1760-4
pubmed: 17673620
Biochem Pharmacol. 2009 Nov 15;78(10):1279-88
pubmed: 19501055
Genome Med. 2014 Aug 26;6(8):61
pubmed: 25191524
Mol Cell. 2021 Jul 15;81(14):2960-2974.e7
pubmed: 34111398
PLoS One. 2010 Jun 29;5(6):e11333
pubmed: 20613874
Int J Med Sci. 2021 Jun 26;18(14):3097-3105
pubmed: 34400880
Cancer Res. 2000 Jan 1;60(1):121-8
pubmed: 10646863
J Biol Chem. 2019 May 31;294(22):8907-8917
pubmed: 31018966
EMBO J. 2013 Feb 6;32(3):340-53
pubmed: 23241950
Int J Biochem Cell Biol. 2019 Sep;114:105558
pubmed: 31238111
Cell Res. 2020 Nov;30(11):980-996
pubmed: 32581343
Development. 2013 Sep;140(17):3565-76
pubmed: 23903187
BMC Genomics. 2015 Aug 20;16:624
pubmed: 26290333
Radiat Res. 2006 Nov;166(5):723-33
pubmed: 17067204
J Biol Chem. 2014 Jan 3;289(1):379-86
pubmed: 24253042
J Biol Chem. 2017 Mar 17;292(11):4533-4543
pubmed: 28115522
Cell Res. 2015 Aug;25(8):911-29
pubmed: 26065575
Nature. 2008 Oct 9;455(7214):822-5
pubmed: 18772889
Int J Cancer. 2020 Oct 15;147(8):2239-2252
pubmed: 32372448
Recent Pat Anticancer Drug Discov. 2011 Jan;6(1):116-30
pubmed: 21110828