Endogenous retroelements as alarms for disruptions to cellular homeostasis.
IFN pathway
cancer
endogenous retroelements
epigenetics
viral mimicry
Journal
Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
17
06
2022
revised:
28
08
2022
accepted:
07
09
2022
pubmed:
11
10
2022
medline:
31
12
2022
entrez:
10
10
2022
Statut:
ppublish
Résumé
Endogenous retroelements are DNA sequences which can duplicate and move to new locations in the genome. Actively moving endogenous retroelements can be disruptive to the host, and their expression is therefore often repressed. Interestingly, drugs that disrupt the repression of endogenous retroelements show promise for treating cancer. Expressed endogenous retroelements can activate innate immune receptors that activate the antiviral response, potentially leading to the death of cancer cells. We discuss disruptions to cellular processes which can lead to activation of the antiviral state from endogenous retroelements, and present the 'fire alarm hypothesis', where we argue that endogenous retroelements act as alarms for disruptions to these cellular processes. Furthermore, we discuss the properties of endogenous retroelements which make them suitable as alarms.
Identifiants
pubmed: 36216729
pii: S2405-8033(22)00191-1
doi: 10.1016/j.trecan.2022.09.001
pii:
doi:
Substances chimiques
Retroelements
0
Antiviral Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
55-68Informations de copyright
Copyright © 2022. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of interests D.D.D.C. reports grants from Princess Margaret Cancer Foundation, the Canadian Institutes of Health Research, and Canada Research Chair during the conduct of the study; grants from Pfizer and other support from Adela, Inc outside the submitted work. The other authors declare no conflicts of interest.