Anti-inflammatory medications for the treatment of mental disorders: A scoping review.
Anti-inflammatory treatment
Inflammation
Mental health
Scoping review
Somatic symptoms
Journal
Brain, behavior, & immunity - health
ISSN: 2666-3546
Titre abrégé: Brain Behav Immun Health
Pays: United States
ID NLM: 101759062
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
17
05
2022
revised:
15
09
2022
accepted:
18
09
2022
entrez:
11
10
2022
pubmed:
12
10
2022
medline:
12
10
2022
Statut:
epublish
Résumé
This scoping review assessed the effect of anti-inflammatory medications in mental disorders. A search in Medline and the Cochrane database focusing on randomised controlled trials and systematic reviews identified 53 primary research articles, conducted in major depression, bipolar disorder, schizophrenia and somatic symptom disorders and related disorders (SSRD). The findings suggest that there is scope to consider the use of anti-inflammatory agents in mental disorders, however, not as a one-size-fits-all solution. Treatment could be especially helpful in subgroups with evidence of baseline inflammation. Anti-inflammatory medications that seem mostly effective in bipolar disorder or major depressive disorder, such as Celecoxib, Pioglitazone and statins, may differ from the ones with indications of effectiveness in schizophrenia, such as Minocycline and Aspirin. This might suggest a different underlying mechanism for treatment success in those two main illness groups. Further studies with larger sample sizes are needed that take levels of inflammation markers into account.
Identifiants
pubmed: 36217374
doi: 10.1016/j.bbih.2022.100518
pii: S2666-3546(22)00108-9
pmc: PMC9547233
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100518Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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