Synthesis of 1,2,3-triazole-thymol derivatives as potential antimicrobial agents.
Ampicillin
Antibacterial activity
Essential oil
Monoterpenoid
Thymol
Triazole
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
16
06
2022
revised:
09
09
2022
accepted:
26
09
2022
entrez:
11
10
2022
pubmed:
12
10
2022
medline:
12
10
2022
Statut:
epublish
Résumé
Thymol as a natural biological template can be modified chemically since the hydroxyl group makes it a candidate for structural modification. Thus, this study incorporated the triazole moiety on thymol and the chlorination of thymol moiety to help improve its biological potency. A series of ten 1,2,3-triazole-thymol derivatives All the synthesized triazole-thymol derivatives showed significant but variable antibacterial activity against the seven medically important bacterial strains tested. The compound 4-((4-chloro-2-isopropyl-5-methylphenoxy)methyl)-1-(2-nitrobenzyl)-1 These results provide additional evidence of the exploitation of natural products like thymol as leads for drug development against medically important bacterial pathogens.
Sections du résumé
Background
UNASSIGNED
Thymol as a natural biological template can be modified chemically since the hydroxyl group makes it a candidate for structural modification. Thus, this study incorporated the triazole moiety on thymol and the chlorination of thymol moiety to help improve its biological potency.
Materials and methods
UNASSIGNED
A series of ten 1,2,3-triazole-thymol derivatives
Results
UNASSIGNED
All the synthesized triazole-thymol derivatives showed significant but variable antibacterial activity against the seven medically important bacterial strains tested. The compound 4-((4-chloro-2-isopropyl-5-methylphenoxy)methyl)-1-(2-nitrobenzyl)-1
Conclusion
UNASSIGNED
These results provide additional evidence of the exploitation of natural products like thymol as leads for drug development against medically important bacterial pathogens.
Identifiants
pubmed: 36217474
doi: 10.1016/j.heliyon.2022.e10836
pii: S2405-8440(22)02124-7
pmc: PMC9547220
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10836Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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