The Toxoplasma plant-like vacuolar compartment (PLVAC).
Toxoplasma gondii
apicomplexan
calcium
digestive
lysosome
plant-like vacuole
vacuolar compartment
zinc
Journal
The Journal of eukaryotic microbiology
ISSN: 1550-7408
Titre abrégé: J Eukaryot Microbiol
Pays: United States
ID NLM: 9306405
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
revised:
06
10
2022
received:
24
06
2022
accepted:
07
10
2022
pubmed:
12
10
2022
medline:
16
11
2022
entrez:
11
10
2022
Statut:
ppublish
Résumé
Toxoplasma gondii belongs to the phylum Apicomplexa and is an important cause of congenital disease and infection in immunocompromised patients. T. gondii shares several characteristics with plants including a nonphotosynthetic plastid termed apicoplast and a multivesicular organelle that was named the plant-like vacuole (PLV) or vacuolar compartment (VAC). The name plant-like vacuole was selected based on its resemblance in composition and function to plant vacuoles. The name VAC represents its general vacuolar characteristics. We will refer to the organelle as PLVAC in this review. New findings in recent years have revealed that the PLVAC represents the lysosomal compartment of T. gondii which has adapted peculiarities to fulfill specific Toxoplasma needs. In this review, we discuss the composition and functions of the PLVAC highlighting its roles in ion storage and homeostasis, endocytosis, exocytosis, and autophagy.
Identifiants
pubmed: 36218001
doi: 10.1111/jeu.12951
pmc: PMC10576567
mid: NIHMS1926259
doi:
Substances chimiques
Protozoan Proteins
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12951Subventions
Organisme : NIAID NIH HHS
ID : R01 AI096836
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI128356
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI060546
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI143707
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI160610
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI120607
Pays : United States
Informations de copyright
© 2022 International Society of Protistologists.
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