Associations of maternal insulin sensitivity during pregnancy with childhood central adiposity in the Genetics of Glucose regulation in Gestation and Growth (Gen3G) cohort.
DXA
central adiposity
insulin sensitivity
mid-childhood
pregnancy
Journal
Pediatric obesity
ISSN: 2047-6310
Titre abrégé: Pediatr Obes
Pays: England
ID NLM: 101572033
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
12
04
2022
accepted:
22
08
2022
pmc-release:
01
02
2024
pubmed:
12
10
2022
medline:
19
1
2023
entrez:
11
10
2022
Statut:
ppublish
Résumé
Childhood obesity has been associated with prenatal exposure to maternal hyperglycaemia, but we lack understanding about maternal insulin physiologic components that contribute to this association. Evaluate the association between maternal insulin sensitivity during pregnancy and adiposity measures in childhood. In 422 mother-child pairs, we tested associations between maternal insulin sensitivity measures at ~26 weeks of pregnancy and child adiposity measures, including dual-energy X-ray absorptiometry body composition and anthropometry (body mass index and waist circumference) at ~5 years. We used linear regression analyses to adjust for maternal age, ethnicity, gravidity, first-trimester body mass index, and child sex and age at mid-childhood. In early pregnancy, maternal mean age was 28.6 ± 4.3 years and median body mass index was 24.1 kg/m Maternal insulin sensitivity during pregnancy may contribute to increased risk for higher offspring central adiposity in middle childhood.
Sections du résumé
BACKGROUND
Childhood obesity has been associated with prenatal exposure to maternal hyperglycaemia, but we lack understanding about maternal insulin physiologic components that contribute to this association.
OBJECTIVES
Evaluate the association between maternal insulin sensitivity during pregnancy and adiposity measures in childhood.
METHODS
In 422 mother-child pairs, we tested associations between maternal insulin sensitivity measures at ~26 weeks of pregnancy and child adiposity measures, including dual-energy X-ray absorptiometry body composition and anthropometry (body mass index and waist circumference) at ~5 years. We used linear regression analyses to adjust for maternal age, ethnicity, gravidity, first-trimester body mass index, and child sex and age at mid-childhood.
RESULTS
In early pregnancy, maternal mean age was 28.6 ± 4.3 years and median body mass index was 24.1 kg/m
CONCLUSIONS
Maternal insulin sensitivity during pregnancy may contribute to increased risk for higher offspring central adiposity in middle childhood.
Identifiants
pubmed: 36218084
doi: 10.1111/ijpo.12982
pmc: PMC9852010
mid: NIHMS1836280
doi:
Substances chimiques
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12982Subventions
Organisme : NICHD NIH HHS
ID : R01 HD094150
Pays : United States
Informations de copyright
© 2022 World Obesity Federation.
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