SARS-CoV-2 vaccination associated venous sinus thrombosis in three patients.
COVID-19
Coronavirus
Hypercoagulability
SARS-CoV-2
Thrombosis
Journal
Journal of applied biomedicine
ISSN: 1214-0287
Titre abrégé: J Appl Biomed
Pays: Poland
ID NLM: 101221755
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
24
02
2022
accepted:
19
07
2022
entrez:
11
10
2022
pubmed:
12
10
2022
medline:
13
10
2022
Statut:
ppublish
Résumé
There is increasing evidence that vaccinations against the severe acquired respiratory syndrome coronavirus type-2 (SARS-CoV-2) virus can be followed by venous sinus thrombosis (VST). Here we report on three patients who developed VST shortly after SARS-CoV-2 vaccinations. An 80-year-old male, a 58-year-old male, and a 34-year-old female developed VST 14 to 24 days after the first dose of an mRNA-based SARS-CoV-2 vaccine. All three patients profited from analgesics, heparinisation, and oral anticoagulation, but made only an incomplete recovery at the time of discharge. Arguments for a causal relationship are: VST was time-linked to vaccination in the three patients; VST was previously reported after SARS-CoV-2 vaccination; SARS-CoV-2 infections can be complicated by VST; and SARS-CoV-2 can be associated with hypercoagulability. The fact that no hypercoagulability occurred in a pilot study after SARS-CoV-2 vaccination and that there has been no evidence of an increased prevalence/incidence of VST after vaccination since the introduction of the SARS-CoV-2 vaccination speak against a causal relationship. SARS-CoV-2 vaccinations can occasionally be followed by a VST. There are more arguments for than against a causal relationship.
Identifiants
pubmed: 36218128
doi: 10.32725/jab.2022.011
doi:
Substances chimiques
Anticoagulants
0
COVID-19 Vaccines
0
RNA, Messenger
0
Viral Vaccines
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
83-86Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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