Penicillactonin and preaustinoid C, lactone-containing metabolites from a hot spring sediment Penicillium sp.
Lactones
Meroterpenoids
NO production
Penicillium
Polyketides
Trichocomaceae
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
22
08
2022
revised:
05
10
2022
accepted:
06
10
2022
pubmed:
12
10
2022
medline:
7
12
2022
entrez:
11
10
2022
Statut:
ppublish
Résumé
Phytochemical investigation of Penicillium sp. RO-11 strain, collected from the sediments of a hydrothermal spring located in the southwestern area of Saudi Arabia, afforded, along with previously isolated compounds, the undescribed polyketides penicillactonin (1), penipyranicin D (4) and isopyrenulin B (5) and the undescribed meroterpenoid preaustinoid C (7). The structures of these compounds were elucidated based on data from mass spectrometry, 1D and 2D NMR, and comparison between experimental and calculated ECD spectra. Penicillactonin and preaustinoid C bring unprecedented structural features, for which a biosynthetic rationale is proposed, further extending the chemodiversity associated to Penicillium fungi. Preaustinoid C showed significant activity against LPS-induced NO production and selective effect on IL-2 and IFN-γ gene regulation in activated Jurkat cells.
Identifiants
pubmed: 36220499
pii: S0367-326X(22)00208-8
doi: 10.1016/j.fitote.2022.105330
pii:
doi:
Substances chimiques
Lactones
0
Polyketides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105330Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.