A risk score for identifying patients at a low risk of bacterial meningitis amongst adults with cerebrospinal fluid leucocytosis and a negative gram stain result: a derivation and validation study.
Antibiotic use
Community-acquired bacterial meningitis
Risk score
Viral encephalitis
Viral meningitis
Journal
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
ISSN: 1469-0691
Titre abrégé: Clin Microbiol Infect
Pays: England
ID NLM: 9516420
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
28
07
2022
revised:
27
09
2022
accepted:
01
10
2022
pubmed:
12
10
2022
medline:
4
3
2023
entrez:
11
10
2022
Statut:
ppublish
Résumé
We aimed to derive and validate a risk score to differentiate patients with bacterial meningitis from those with viral meningitis or encephalitis amongst patients presenting with cerebrospinal fluid (CSF) leucocytosis and a negative Gram staining result. We included adults with bacterial and viral meningitis or encephalitis presenting with CSF leukocyte counts of >10 per mm Derivation was performed in 109 American patients with bacterial meningitis (median age, 56 years; interquartile range [IQR], 46-66 years; 46% women) and 194 with viral meningitis or encephalitis (median age, 46 years; IQR, 33-60 years; 53% women). Serum leukocyte counts of >10.0 × 10 Our risk score may be able to rule out bacterial meningitis amongst patients presenting with CSF leucocytosis and a negative Gram staining result. However, it needs prospective testing prior to clinical implementation.
Identifiants
pubmed: 36220627
pii: S1198-743X(22)00514-6
doi: 10.1016/j.cmi.2022.10.001
pii:
doi:
Substances chimiques
Gram's stain
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
360-365Informations de copyright
Copyright © 2022 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.