Up-Regulated Proteins Have More Protein-Protein Interactions than Down-Regulated Proteins.
Journal
The protein journal
ISSN: 1875-8355
Titre abrégé: Protein J
Pays: Netherlands
ID NLM: 101212092
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
accepted:
01
10
2022
pubmed:
12
10
2022
medline:
19
11
2022
entrez:
11
10
2022
Statut:
ppublish
Résumé
Microarray technology has been successfully used in many biology studies to solve the protein-protein interaction (PPI) prediction computationally. For normal tissue, the cell regulation process begins with transcription and ends with the translation process. However, when cell regulation activity goes wrong, cancer occurs. Microarray data can precisely give high accuracy expression levels at normal and cancer-affected cells, which can be useful for the identification of disease-related genes. First, the differentially expressed genes (DEGs) are extracted from the cancer microarray dataset in order to identify the genes that are up-regulated and down-regulated during cancer progression in the human body. Then, proteins corresponding to these genes are collected from NCBI, and then the STRING web server is used to build the PPI network of these proteins. Interestingly, up-regulated proteins have always a higher number of PPIs compared to down-regulated proteins, although, in most of the datasets, the majority of these DEGs are down-regulated. We hope this study will help to build a relevant model to analyze the process of cancer progression in the human body.
Identifiants
pubmed: 36221012
doi: 10.1007/s10930-022-10081-6
pii: 10.1007/s10930-022-10081-6
pmc: PMC9552713
doi:
Substances chimiques
Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
591-595Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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