Health-related quality of life among breast cancer patients in India.
Breast cancer
Breast conservative surgery
EORTC
EORTC QLQ-BR23
EQ-5D
Health-related quality of life
India
Modified radical mastectomy
Patient-reported outcomes
Quality of life
Utility score
Journal
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
ISSN: 1433-7339
Titre abrégé: Support Care Cancer
Pays: Germany
ID NLM: 9302957
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
18
04
2022
accepted:
04
10
2022
pubmed:
13
10
2022
medline:
6
12
2022
entrez:
12
10
2022
Statut:
ppublish
Résumé
This study evaluated the health-related quality of life (HRQoL) among breast cancer patients during various phases of treatment and with different treatment modalities, which helps in monitoring treatment outcomes, assessing the well-being of patients, and conducting health technology assessments. A total of 534 interviews were conducted among the patients of breast cancer recruited at different stages of disease and with different treatment modalities. HRQoL was determined using EuroQoL five dimensions questionnaire with five levels (EQ-5D-5L), EuroQoL Visual Analogue Scale (EQ VAS), and the EORTC QLQ-BR23 instrument. The utility values were determined based on the Indian EQ-5D-5L value set. The socio-demographic and clinico-therapeutic determinants of HRQoL were evaluated using multiple linear regression. The mean utility value of breast cancer patients was 0.602 (SD = 0.311) and mean EQ VAS score was 75 (SD = 12.3). The mean utility value at diagnosis was 0.628, whereas utility value was 0.55, 0.595, and 0.64 for post-surgery, post-chemotherapy, and post-radiotherapy treatment groups, respectively. The most frequently reported problem was pain/discomfort (in 84.3% patients), followed by anxiety/depression (83.5%). On EORTC QLQ-BR23, the maximum symptom scale scores for systemic therapy side effects were reported in the post chemotherapy group. The body image score and future perspective score were better in patients undergoing breast conservative surgery (BCS) compared to patients undergoing modified radical mastectomy. Age, education, and employment status of the patient, type of treatment modality, and use of taxanes are the determinants of HRQoL in breast cancer patients. Clinical interventions should focus upon management of pain and anxiety. BCS should be offered to all eligible patients as it is associated with better HRQoL. Addressing the factors that independently affect the HRQoL will help in improving the treatment compliance and outcomes.
Identifiants
pubmed: 36222977
doi: 10.1007/s00520-022-07395-7
pii: 10.1007/s00520-022-07395-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9983-9990Subventions
Organisme : Department of Science & Technology & Renewable Energy, Chandigarh Administration
ID : S&T&RE/RP/147/(19-20)/Sanc/10/2019/1703-1710
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249. https://doi.org/10.3322/caac.21660
doi: 10.3322/caac.21660
pubmed: 33538338
Cancer Statistics - India Against Cancer [Internet]. India Against Cancer. 2022 [cited 4 April 2022]. Available from: http://cancerindia.org.in/cancer-statistics/ .
Mokhtari-Hessari P, Montazeri A (2020) Health-related quality of life in breast cancer patients: review of reviews from 2008 to 2018. Health Qual Life Outcomes 18(1):338. https://doi.org/10.1186/s12955-020-01591-x.Erratum.In:HealthQualLifeOutcomes.2022Feb25;20(1):35
doi: 10.1186/s12955-020-01591-x.Erratum.In:HealthQualLifeOutcomes.2022Feb25;20(1):35
pubmed: 33046106
pmcid: 7552560
Azamjah N, Zadeh YS, Zayeri F (2019) Global trend of breast cancer mortality rate: a 25-year study. Asian Pac J Cancer Prev 20(7):2015. https://doi.org/10.31557/APJCP.2019.20.7.2015
doi: 10.31557/APJCP.2019.20.7.2015
pubmed: 31350959
pmcid: 6745227
Russell KM, Von Ah DM, Giesler RB, Storniolo AM, Haase JE (2008) Quality of life of African American breast cancer survivors: how much do we know? Cancer Nurs 31(6):E36-45
doi: 10.1097/01.NCC.0000339254.68324.d7
pubmed: 18987506
Delgado-Sanz MC, Garcia-Mendizabal MJ, Pollan M et al (2011) Heath-related quality of life in Spanish breast cancer patients: a systematic review. Health Qual Life Outcomes 9(1):3
doi: 10.1186/1477-7525-9-3
pubmed: 21235770
pmcid: 3031190
Rangarajan B, Shet T, Wadasadawala T, Nair NS, Sairam RM, Hingmire SS et al (2016) Breast cancer: an overview of published Indian data. South Asian J Cancer 5(3):86–92
doi: 10.4103/2278-330X.187561
pubmed: 27606288
pmcid: 4991144
Roudijk B, Donders ART, Stalmeier PFM (2019) Cultural values group. Cultural Values: Can They Explain Differences in Health Utilities between Countries? Med Decis Making 39(5):605–16
doi: 10.1177/0272989X19841587
pubmed: 31257997
pmcid: 6791017
Jyani G, Prinja S, Kar SS, Trivedi M, Patro B, Purba F et al (2020) Valuing health-related quality of life among the Indian population: a protocol for the Development of an EQ-5D Value set for India using an Extended design (DEVINE) Study. BMJ Open 10(11):e039517. https://doi.org/10.1136/bmjopen-2020-039517
doi: 10.1136/bmjopen-2020-039517
pubmed: 33444194
pmcid: 7682473
Damodar G, Smitha T, Gopinath S, Vijayakumar S, Rao YA (2013) Assessment of quality of life in breast cancer patients at a tertiary care hospital. Arch Pharma Pract 4:15–20. https://doi.org/10.4103/2045-080X.111577
doi: 10.4103/2045-080X.111577
Dubashi B, Vidhubala E, Cyriac S, Sagar TG (2010) Quality of life among younger women with breast cancer: study from a tertiary cancer institute in south India. Indian J Cancer 47(2):142–7
doi: 10.4103/0019-509X.63005
pubmed: 20448376
Gangane N, Khairkar P, Hurtig AK, Sebastián MS (2017) Quality of life determinants in breast cancer patients in central rural India. Asian Pac J Cancer Prev 18(12):3325–3332
pubmed: 29286227
pmcid: 5980891
Imran M, Al-Wassia R, Alkhayyat SS, Baig M, Al-Saati BA (2019) Assessment of quality of life (QoL) in breast cancer patients by using EORTC QLQ-C30 and BR-23 questionnaires: a tertiary care center survey in the western region of Saudi Arabia. PLoS ONE 14(7):e0219093
doi: 10.1371/journal.pone.0219093
pubmed: 31291302
pmcid: 6620008
Arndt V, Stegmaier C, Ziegler H, Brenner H (2008) Quality of life over 5 years in women with breast cancer after breast-conserving therapy versus mastectomy: a population-based study. J Cancer Res Clin Oncol 134:1311–8
doi: 10.1007/s00432-008-0418-y
pubmed: 18504613
Prinja S, Jyani G, Gupta N, Rajsekar K (2021) Adapting health technology assessment for drugs, medical devices, and health programs: methodological considerations from the Indian experience. Expert Rev Pharmacoecon Outcomes Res 21(5):859–868. https://doi.org/10.1080/14737167.2021.1921575
doi: 10.1080/14737167.2021.1921575
pubmed: 33882762
Prinja S, Downey LE, Gauba VK, Swaminathan S (2018) Health technology assessment for policy making in India: current scenario and way forward. PharmacoEconomics - Open 2(1):1–3
doi: 10.1007/s41669-017-0037-0
pubmed: 29464668
Prinja S, Rajsekhar K, Gauba VK (2020) Health technology assessment in India: reflection and future roadmap. Indian J Med Res 152(5):444–447
doi: 10.4103/ijmr.IJMR_115_19
pubmed: 33707385
pmcid: 8157896
Enien MA, Ibrahim N, Makar W, Darwish D, Gaber M (2018) Health-related quality of life: Impact of surgery and treatment modality in breast cancer. J Can Res Ther 14:957–963
doi: 10.4103/0973-1482.183214
Pakseresht S, Ingle GK, Garg S (2011) Quality of life of women with breast cancer at the time of diagnosis in New Delhi. J Cancer Sci Ther 3:66–69. https://doi.org/10.4172/1948-5956.1000060
doi: 10.4172/1948-5956.1000060
Kind P. (1996) The EuroQol instrument: an index of health-related quality of life. In Quality of life and pharmacoeconomics in clinical trials. Edited by: Spiker B. Philadelphia: Lippincott-Raven Publishers 191-201.
Jyani G, Chauhan AS, Rai B, Ghoshal S, Srinivasan R, Prinja S (2020) Health-related quality of life among cervical cancer patients in India. Int J Gynecol Cancer 30(12):1887–1892. https://doi.org/10.1136/ijgc-2020-001455
doi: 10.1136/ijgc-2020-001455
pubmed: 32788265
Rabin R, de Charro F (2001) EQ-5D: a measure of health status from the EuroQol Group. Ann Med 33(5):337–343
doi: 10.3109/07853890109002087
pubmed: 11491192
Sprangers MA, Groenvold M, Arraras JI, Franklin J, te Velde A, Muller M et al (1996) The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study. J Clin Oncol 14(10):2756–2768. https://doi.org/10.1200/JCO.1996.14.10.2756
doi: 10.1200/JCO.1996.14.10.2756
pubmed: 8874337
Jyani G, Sharma A, Prinja S, Kar SS, Trivedi M, Patro BK, Goyal A, Purba FD, Finch AP, Rajsekar K, Raman S, Stolk E, Kaur M (2022) Development of an EQ-5D Value Set for India using an Extended Design (DEVINE) Study: The Indian 5-Level version EQ-5D Value Set. Value Health 25(7):1218–1226. https://doi.org/10.1016/j.jval.2021.11.1370
doi: 10.1016/j.jval.2021.11.1370
pubmed: 35779943
Shayne M, Crawford J, Dale DC et al (2006) Predictors of reduced dose intensity in patients with early-stage breast cancer receiving adjuvant chemotherapy. Breast Cancer Res Treat 100(3):255–262
doi: 10.1007/s10549-006-9254-4
pubmed: 16705366
Sio TT, Chang K, Jayakrishnan R, Wu D, Politi M, Malacarne D et al (2014) Patient age is related to decision-making, treatment selection, and perceived quality of life in breast cancer survivors. World J Surg Oncol 12:230. https://doi.org/10.1186/1477-7819-12-230
doi: 10.1186/1477-7819-12-230
pubmed: 25052797
pmcid: 4113127
Konieczny M, Cipora E, Sygit K, Fal A (2020) Quality of life of women with breast cancer and socio-demographic factors. Asian Pac J Cancer Prev 21(1):185–193
doi: 10.31557/APJCP.2020.21.1.185
pubmed: 31983183
pmcid: 7294011
Al Zahrani AM, Alalawi Y, Yagoub U, Saud N, Siddig K (2019) Quality of life of women with breast cancer undergoing treatment and follow-up at King Salman Armed Forces Hospital in Tabuk Saudi Arabia. Breast Cancer: Targets Ther 11:199–208
Gupta N, Jyani G, Rajsekar K, Gupta R, Nagar A, Gedam P et al (2021) Application of health technology assessment for oncology care in India: implications for Ayushman Bharat Pradhan Mantri Jan Aarogya Yojana. Indian J Med Paediatr Oncol 42(05):479–483. https://doi.org/10.1055/s-0041-1740536
doi: 10.1055/s-0041-1740536
Sharma N, Purkayastha A (2017) Factors affecting quality of life in breast cancer patients: a descriptive and cross-sectional study with review of literature. J Mid-life Health 8:75–83
doi: 10.4103/jmh.JMH_15_17
Freire MEM, Sawada NO, de França ISX, da Costa SFG, Oliveira CDV (2014) Health-related quality of life among patients with advanced cancer: an integrative review. Rev Esc Enferm USP 48(2):357–367
doi: 10.1590/S0080-6234201400002000022
pubmed: 24918897
A Compendium of Health Technology Assessment in India. HTAIn Secretariat, Department of Health Research, Ministry of Health & Family Welfare, Government of India. 2019. [Cited 8 September 2022] Available from: https://htain.icmr.org.in/images/pdf/Compendium_v8.pdf