Outdoor light at night and risk of endometrial cancer in the NIH-AARP diet and health study.
Cancer
Circadian rhythm
Endometrial neoplasms
Environmental epidemiology
Lighting
Journal
Cancer causes & control : CCC
ISSN: 1573-7225
Titre abrégé: Cancer Causes Control
Pays: Netherlands
ID NLM: 9100846
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
17
03
2022
accepted:
15
09
2022
pubmed:
13
10
2022
medline:
28
1
2023
entrez:
12
10
2022
Statut:
ppublish
Résumé
Outdoor light at night (LAN) can result in circadian disruption and hormone dysregulation and is a suspected risk factor for some cancers. Our study is the first to evaluate the association between LAN and risk of endometrial cancer, a malignancy with known relationship to circulating estrogen levels. We linked enrollment addresses (1996) for 97,677 postmenopausal women in the prospective NIH-AARP cohort to satellite imagery of nighttime radiance to estimate LAN exposure. Multivariable Cox models estimated hazard ratios (HR) and 95% confidence intervals (95% CI) for LAN quintiles and incident endometrial cancer overall (1,669 cases) and endometrioid adenocarcinomas (991 cases) through follow-up (2011). We tested for interaction with established endometrial cancer risk factors. We observed no association for endometrial cancer overall (HR Our study did not find an association between outdoor LAN and endometrial cancer risk, but was limited by the inability to account for individual-level exposure determinants. Future studies should consider approaches to improve characterization of personal exposures to light.
Identifiants
pubmed: 36222982
doi: 10.1007/s10552-022-01632-4
pii: 10.1007/s10552-022-01632-4
pmc: PMC10236480
mid: NIHMS1898235
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
181-187Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL150119
Pays : United States
Organisme : Intramural NIH HHS
ID : Z99 CA999999
Pays : United States
Informations de copyright
© 2022. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
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