Interoperability of RTN1A in dendrite dynamics and immune functions in human Langerhans cells.
Animals
Dendrites
/ immunology
Epidermis
/ metabolism
Humans
Immunity
Langerhans Cells
/ immunology
Lipoproteins
/ metabolism
Mice
Nerve Tissue Proteins
/ metabolism
RNA
/ metabolism
Toll-Like Receptor 1
/ metabolism
Toll-Like Receptor 2
/ metabolism
Toll-Like Receptor 7
/ metabolism
Toll-Like Receptors
/ metabolism
Langerhans cells
RTN1A
Toll-like receptors
cytoskeleton
dendrites
epidermis
human
immunology
inflammation
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
12 10 2022
12 10 2022
Historique:
received:
25
05
2022
accepted:
09
09
2022
entrez:
12
10
2022
pubmed:
13
10
2022
medline:
15
10
2022
Statut:
epublish
Résumé
Skin is an active immune organ where professional antigen-presenting cells such as epidermal Langerhans cells (LCs) link innate and adaptive immune responses. While Reticulon 1A (RTN1A) was recently identified in LCs and dendritic cells in cutaneous and lymphoid tissues of humans and mice, its function is still unclear. Here, we studied the involvement of this protein in cytoskeletal remodeling and immune responses toward pathogens by stimulation of Toll-like receptors (TLRs) in resident LCs (rLCs) and emigrated LCs (eLCs) in human epidermis ex vivo and in a transgenic THP-1 RTN1A
Identifiants
pubmed: 36223176
doi: 10.7554/eLife.80578
pii: 80578
pmc: PMC9555864
doi:
pii:
Substances chimiques
Lipoproteins
0
Nerve Tissue Proteins
0
RTN1 protein, human
0
Toll-Like Receptor 1
0
Toll-Like Receptor 2
0
Toll-Like Receptor 7
0
Toll-Like Receptors
0
RNA
63231-63-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022, Cichoń, Cichoń et al.
Déclaration de conflit d'intérêts
MC, KP, JL, LW, CS, PS, AE No competing interests declared
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