Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2022
2022
Historique:
received:
26
01
2021
accepted:
06
09
2022
entrez:
12
10
2022
pubmed:
13
10
2022
medline:
15
10
2022
Statut:
epublish
Résumé
The causes that trigger the onset of dementia are still unknown. Recently there has been an increasing interest in the possible role of infectious agents in the brain in the pathogenesis of this condition. Amongst the viruses, members of the Herpesviridae family, namely herpes simplex virus-1 (HSV1), cytomegalovirus (CMV), human herpesvirus-6 (HHV6), human herpesvirus-7 (HHV7) and varicella zoster virus (VZV) have been suggested as potential causes of the disease. However, the relative importance of these and other viruses in contributing to dementia remains unclear. We evaluated the association between seropositivity status of all viruses available in a large, population-based dataset (the UK Biobank) and dementia risk in an unbiased way. Of the 15 viruses investigated, our results showed a statistically significant increase of dementia risk associated only with HSV1 seropositivity (OR 2.14, 95% C.I. 1.21-3.81). However, by combining the data we found that seropositivity for 4 viruses (HSV1, HHV6, HHV7 and VZV) also significantly increases the risk of dementia (OR = 2.37, 95% C.I. 1.43-3.92). These four viruses have been described previously as neurotropic viruses. Our results provide support for a role for neurotropic viruses in the pathology of dementia.
Identifiants
pubmed: 36223333
doi: 10.1371/journal.pone.0274872
pii: PONE-D-21-02849
pmc: PMC9555633
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0274872Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
J Virol Methods. 2014 Apr;199:29-34
pubmed: 24418499
Pharmacogenomics. 2005 Sep;6(6):639-46
pubmed: 16143003
J Pathol. 2002 Jul;197(3):395-402
pubmed: 12115887
J Alzheimers Dis. 2012;30(4):779-90
pubmed: 22466000
PLoS Pathog. 2019 Mar 14;15(3):e1007617
pubmed: 30870531
Alzheimers Dement (N Y). 2019 Nov 04;5:697-704
pubmed: 31921962
Alzheimers Dement. 2020 Jan;16(1):200-208
pubmed: 31914220
Front Aging Neurosci. 2014 Oct 15;6:285
pubmed: 25360113
Acta Neuropathol. 2016 Feb;131(2):159-184
pubmed: 26659576
J Med Virol. 2012 Nov;84(11):1797-802
pubmed: 22997083
J Alzheimers Dis. 2019;67(1):211-220
pubmed: 30636735
Eur Arch Psychiatry Clin Neurosci. 2021 Aug;271(5):987-997
pubmed: 32613564
J Infect Dis. 2015 Jan 15;211(2):230-7
pubmed: 25108028
J Alzheimers Dis. 2018;64(2):363-366
pubmed: 29889070
Neuron. 2018 Jul 11;99(1):64-82.e7
pubmed: 29937276
Sci Adv. 2020 May 06;6(19):eaay8828
pubmed: 32494701
J Infect Dis. 2003 May 1;187(9):1377-87
pubmed: 12717618
Eur J Epidemiol. 2019 Jun;34(6):557-565
pubmed: 30806901
CMAJ. 2001 Nov 27;165(11):1495-8
pubmed: 11762573
J Alzheimers Dis. 2014;38(4):741-5
pubmed: 24072067
Int Psychogeriatr. 2009 Dec;21(6):1096-104
pubmed: 19712540
Nature. 2018 Oct;562(7726):203-209
pubmed: 30305743
Am J Epidemiol. 2017 Nov 1;186(9):1026-1034
pubmed: 28641372
Stroke. 2003 Sep;34(9):2126-31
pubmed: 12920256
J Clin Psychiatry. 2018 Jan/Feb;79(1):
pubmed: 29244265
Nat Commun. 2022 Apr 5;13(1):1818
pubmed: 35383168
J Clin Epidemiol. 2001 Apr;54(4):343-9
pubmed: 11297884
Neurotherapeutics. 2018 Apr;15(2):417-429
pubmed: 29488144
PLoS Med. 2015 Mar 31;12(3):e1001779
pubmed: 25826379
J Infect Dis. 2015 Jun 15;211(12):2023-4
pubmed: 25635119
PLoS Genet. 2018 Nov 2;14(11):e1007427
pubmed: 30388101
PLoS One. 2008;3(11):e3637
pubmed: 18982063