Amoxicillin Did Not Reduce Modic Change Edema in Patients With Chronic Low Back Pain: Subgroup Analyses of a Randomised Trial (the AIM Study).


Journal

Spine
ISSN: 1528-1159
Titre abrégé: Spine (Phila Pa 1976)
Pays: United States
ID NLM: 7610646

Informations de publication

Date de publication:
01 Feb 2023
Historique:
received: 17 02 2022
accepted: 05 10 2022
pubmed: 13 10 2022
medline: 11 1 2023
entrez: 12 10 2022
Statut: ppublish

Résumé

Exploratory subgroup analyses of a randomised trial [Antibiotics in Modic changes (AIM) study]. The aim was to assess the effect of amoxicillin versus placebo in reducing Modic change (MC) edema in patients with chronic low back pain. The AIM study showed a small, clinically insignificant effect of amoxicillin on pain-related disability in patients with chronic low back pain and MC type 1 (edema type) on magnetic resonance imaging (MRI). A total of 180 patients were randomised to receive 100 days of amoxicillin or placebo. MC edema was assessed on MRI at baseline and one-year follow-up. Per-protocol analyses were conducted in subgroups with MC edema on short tau inversion recovery (STIR) or T1/T2-weighted MRI at baseline. MC edema reductions (yes/no) in STIR and T1/T2 series were analyzed separately. The effect of amoxicillin in reducing MC edema was analyzed using logistic regression adjusted for prior disk surgery. To assess the effect of amoxicillin versus placebo within the group with the most abundant MC edema on STIR at baseline ("STIR3" group), we added age, STIR3 (yes/no), and STIR3×treatment group (interaction term) as independent variables and compared the marginal means (probabilities of edema reduction). Compared to placebo, amoxicillin did not reduce MC edema on STIR (volume/intensity) in the total sample with edema on STIR at baseline (odds ratio 1.0, 95% CI: 0.5, 2.0; n=141) or within the STIR3 group (probability of edema reduction 0.69, 95% CI: 0.47, 0.92 with amoxicillin and 0.61, 95% CI: 0.43, 0.80 with placebo; n=41). Compared with placebo, amoxicillin did not reduce MC edema in T1/T2 series (volume of the type 1 part of MCs) (odds ratio: 1.0, 95% CI: 0.5, 2.3, n=104). Edema declined in >50% of patients in both treatment groups. From baseline to one-year follow-up, amoxicillin did not reduce MC edema compared with placebo. 2.

Sections du résumé

STUDY DESIGN METHODS
Exploratory subgroup analyses of a randomised trial [Antibiotics in Modic changes (AIM) study].
OBJECTIVE OBJECTIVE
The aim was to assess the effect of amoxicillin versus placebo in reducing Modic change (MC) edema in patients with chronic low back pain.
SUMMARY OF BACKGROUND DATA BACKGROUND
The AIM study showed a small, clinically insignificant effect of amoxicillin on pain-related disability in patients with chronic low back pain and MC type 1 (edema type) on magnetic resonance imaging (MRI).
MATERIALS AND METHODS METHODS
A total of 180 patients were randomised to receive 100 days of amoxicillin or placebo. MC edema was assessed on MRI at baseline and one-year follow-up. Per-protocol analyses were conducted in subgroups with MC edema on short tau inversion recovery (STIR) or T1/T2-weighted MRI at baseline. MC edema reductions (yes/no) in STIR and T1/T2 series were analyzed separately. The effect of amoxicillin in reducing MC edema was analyzed using logistic regression adjusted for prior disk surgery. To assess the effect of amoxicillin versus placebo within the group with the most abundant MC edema on STIR at baseline ("STIR3" group), we added age, STIR3 (yes/no), and STIR3×treatment group (interaction term) as independent variables and compared the marginal means (probabilities of edema reduction).
RESULTS RESULTS
Compared to placebo, amoxicillin did not reduce MC edema on STIR (volume/intensity) in the total sample with edema on STIR at baseline (odds ratio 1.0, 95% CI: 0.5, 2.0; n=141) or within the STIR3 group (probability of edema reduction 0.69, 95% CI: 0.47, 0.92 with amoxicillin and 0.61, 95% CI: 0.43, 0.80 with placebo; n=41). Compared with placebo, amoxicillin did not reduce MC edema in T1/T2 series (volume of the type 1 part of MCs) (odds ratio: 1.0, 95% CI: 0.5, 2.3, n=104). Edema declined in >50% of patients in both treatment groups.
CONCLUSIONS CONCLUSIONS
From baseline to one-year follow-up, amoxicillin did not reduce MC edema compared with placebo.
LEVEL OF EVIDENCE METHODS
2.

Identifiants

pubmed: 36223435
doi: 10.1097/BRS.0000000000004513
pii: 00007632-202302010-00001
pmc: PMC9812422
doi:

Substances chimiques

Amoxicillin 804826J2HU
Anti-Bacterial Agents 0

Types de publication

Randomized Controlled Trial Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

147-154

Informations de copyright

Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.

Déclaration de conflit d'intérêts

The authors report no conflicts of interest.

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Auteurs

Per M Kristoffersen (PM)

Department of Radiology, Haukeland University Hospital, Bergen, Norway.
Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Nils Vetti (N)

Department of Radiology, Haukeland University Hospital, Bergen, Norway.
Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Lars Grøvle (L)

Department of Rheumatology, Østfold Hospital Trust, Moss, Norway.

Jens I Brox (JI)

Faculty of Medicine, University of Oslo, Oslo, Norway.
Department of Physical Medicine and Rehabilitation, Oslo University Hospital HF, Oslo, Norway.

Lars C Haugli Bråten (LC)

Division of Clinical Neuroscience, Department of Research and Innovation, Oslo University Hospital, Oslo, Norway.

Margreth Grotle (M)

Division of Clinical Neuroscience, Department of Research and Innovation, Oslo University Hospital, Oslo, Norway.
Department of Rehabilitation and Technology, Faculty of Health Science, OsloMet-Oslo Metropolitan University, Oslo, Norway.

Anne Julsrud Haugen (A)

Department of Rheumatology, Østfold Hospital Trust, Moss, Norway.

Mads P Rolfsen (MP)

Faculty of Medicine, University of Oslo, Oslo, Norway.
Department of Orthopaedic Surgery, Oslo University Hospital, Oslo, Norway.

Anne Froholdt (A)

Department of Physical Medicine and Rehabilitation, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway.

Jan S Skouen (JS)

Department of Physical Medicine and Rehabilitation, Haukeland University Hospital, Helse Bergen HF, Bergen, Norway.
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Olav Lutro (O)

Department of Medicine, Stavanger University Hospital, Stavanger, Norway.

Gunn H Marchand (GH)

Departement of Physical Medicine and Rehabilitation, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Departement of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Audny Anke (A)

Department of Rehabilitation, University Hospital of North Norway, Tromsø, Norway.
Faculty of Health Sciences, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway.

John-Anker Zwart (JA)

Faculty of Medicine, University of Oslo, Oslo, Norway.
Division of Clinical Neuroscience, Department of Research and Innovation, Oslo University Hospital, Oslo, Norway.

Kjersti Storheim (K)

Division of Clinical Neuroscience, Department of Research and Innovation, Oslo University Hospital, Oslo, Norway.
Department of Rehabilitation and Technology, Faculty of Health Science, OsloMet-Oslo Metropolitan University, Oslo, Norway.

Jörg Assmus (J)

Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway.

Ansgar Espeland (A)

Department of Radiology, Haukeland University Hospital, Bergen, Norway.
Department of Clinical Medicine, University of Bergen, Bergen, Norway.

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