Insulin resistance and adipose tissue inflammation induced by a high-fat diet are attenuated in the absence of hepcidin.
Adipose tissue
Hepcidin
Inflammation
Insulin resistance
Iron
Macrophage
Journal
The Journal of nutritional biochemistry
ISSN: 1873-4847
Titre abrégé: J Nutr Biochem
Pays: United States
ID NLM: 9010081
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
16
09
2021
revised:
15
06
2022
accepted:
17
08
2022
pubmed:
13
10
2022
medline:
1
12
2022
entrez:
12
10
2022
Statut:
ppublish
Résumé
Increased body iron stores and inflammation in adipose tissue have been implicated in the pathogenesis of insulin resistance (IR) and type 2 diabetes mellitus. However, the underlying basis of these associations is unclear. To attempt to investigate this, we studied the development of IR and associated inflammation in adipose tissue in the presence of increased body iron stores. Male hepcidin knock-out (Hamp1
Identifiants
pubmed: 36223834
pii: S0955-2863(22)00243-1
doi: 10.1016/j.jnutbio.2022.109175
pii:
doi:
Substances chimiques
Hepcidins
0
Insulin
0
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109175Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.