A case of malignant melanoma, a possible primary site in the digit, with systemic metastasis in a mini-Rex.
bone marrow
digit
malignant melanoma
mini-Rex
rabbit
Journal
The Journal of veterinary medical science
ISSN: 1347-7439
Titre abrégé: J Vet Med Sci
Pays: Japan
ID NLM: 9105360
Informations de publication
Date de publication:
18 Nov 2022
18 Nov 2022
Historique:
pubmed:
13
10
2022
medline:
23
11
2022
entrez:
12
10
2022
Statut:
ppublish
Résumé
We report a case of systemic metastasis of malignant melanoma in a mini-Rex (Oryctolagus cuniculus). The animal presented with lameness of the right hind limb, swelling of popliteal lymph node, and a black mass on the first digit. Paralysis of hindlimbs and forelimbs, dysuria, and dysphagia progressed over time, and the rabbit died on day 35 from the first visit. At necropsy, many black lesions were observed in multiple organs including the marrow of most bones. Histopathologically, the tumor cells had highly atypical nuclei of various sizes and an abundant eosinophilic cytoplasm, and some cells contained melanin granules. These cells were positive for PNL2 and S-100, melanoma markers, by immunohistochemistry. This is the first report of malignant melanoma in a mini-Rex with severe malignancy and systemic metastasis including the bone marrow.
Identifiants
pubmed: 36223952
doi: 10.1292/jvms.22-0181
pmc: PMC9791239
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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