Disturbances in microbial skin recolonization and cutaneous immune response following allogeneic stem cell transfer.

Humans Hematopoietic Stem Cell Transplantation / adverse effects Graft vs Host Disease / etiology Gastrointestinal Microbiome Immunity

Journal

Leukemia

ISSN: 1476-5551

Titre abrégé: Leukemia

Pays: England

ID NLM: 8704895

Informations de publication

Date de publication:
Nov 2022

Historique:

received: 05 05 2022

accepted: 15 09 2022

revised: 09 09 2022

pubmed: 13 10 2022

medline: 1 11 2022

entrez: 12 10 2022

Statut: ppublish

Résumé

The composition of the gut microbiome influences the clinical course after allogeneic hematopoietic stem cell transplantation (HSCT), but little is known about the relevance of skin microorganisms. In a single-center, observational study, we recruited a cohort of 50 patients before undergoing conditioning treatment and took both stool and skin samples up to one year after HSCT. We could confirm intestinal dysbiosis following HSCT and report that the skin microbiome is likewise perturbed in HSCT-recipients. Overall bacterial colonization of the skin was decreased after conditioning. Particularly patients that developed acute skin graft-versus-host disease (aGVHD) presented with an overabundance of Staphylococcus spp. In addition, a loss in alpha diversity was indicative of aGVHD development already before disease onset and correlated with disease severity. Further, co-localization of CD45

Identifiants

DOI: 10.1038/s41375-022-01712-z PMID: 36224329

pubmed: 36224329

doi: 10.1038/s41375-022-01712-z

pii: 10.1038/s41375-022-01712-z

doi:

Types de publication

Observational Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

2705-2714

Commentaires et corrections

Type : ErratumIn

Informations de copyright

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