Variation in Gut Microbiota Composition is Associated with Sleep Quality and Cognitive Performance in Older Adults with Insomnia.
actigraphy
cognition
microbiome
older adults
sleep efficiency
Journal
Nature and science of sleep
ISSN: 1179-1608
Titre abrégé: Nat Sci Sleep
Pays: New Zealand
ID NLM: 101537767
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
06
2022
accepted:
30
08
2022
entrez:
13
10
2022
pubmed:
14
10
2022
medline:
14
10
2022
Statut:
epublish
Résumé
Insomnia, a chronic condition affecting 50% of older adults, is often accompanied by cognitive decline. The mechanism underlying this comorbidity is not fully understood. A growing literature suggests the importance of gut microbiota for brain function. We tested associations between sleep quality and cognitive performance with gut microbiota in older adults with insomnia. Seventy-two older adults with insomnia (age 73.2 ± 5.73 years, 56 females) provided stool samples for gut microbial sequencing. Microbiota profile was determined using the DADA2 bioinformatics pipeline. Cognition was assessed with the Cambridge Neuropsychological Test Automated Battery. Objective sleep quality was monitored by a two-week actigraphic recording, and participants completed the Insomnia Severity Index (ISI). We used partial canonical correspondence analysis (pCCA) to examine the relative contribution of insomnia, based on actigraphic sleep efficiency (SE) and ISI, and of cognitive status, based on the Multitasking test of Median Reaction Latency (MTTLMD) and the Spatial Working Memory Between Errors (SWMBE), to variance in microbiota composition. We used Pearson correlations to correlate insomnia and cognitive status parameters with microbiota amplicon sequence variants, genera, and families. The pCCA revealed that sleep quality and cognitive performance explained a variation of 7.5-7.9% in gut microbiota composition in older adults with insomnia. Correlation analysis demonstrated that Findings demonstrate the associations of sleep quality and cognitive performance with variance in gut microbiota composition and with specific genus abundance in older adults with insomnia. Further studies should validate the findings, determine causal relationships, and evaluate potential interventions for the comorbidity of insomnia and cognitive impairment in older adults with insomnia.
Identifiants
pubmed: 36225322
doi: 10.2147/NSS.S377114
pii: 377114
pmc: PMC9550024
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1753-1767Informations de copyright
© 2022 Haimov et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Gastroenterol Clin North Am. 2017 Mar;46(1):77-89
pubmed: 28164854
Neurobiol Stress. 2017 Mar 19;7:124-136
pubmed: 29276734
J Sleep Res. 2008 Mar;17(1):23-33
pubmed: 18275552
Sleep. 2004 Dec 15;27(8):1479-85
pubmed: 15683137
World J Gastroenterol. 2018 Jan 7;24(1):5-14
pubmed: 29358877
Sleep. 2006 Sep;29(9):1155-73
pubmed: 17040003
JAMA Netw Open. 2022 Feb 1;5(2):e2143941
pubmed: 35133436
Environ Microbiol. 2016 May;18(5):1403-14
pubmed: 26271760
Sleep Med. 2020 Sep;73:76-81
pubmed: 32795890
PLoS One. 2013;8(4):e61390
pubmed: 23577218
BMC Microbiol. 2009 Jun 09;9:123
pubmed: 19508720
Trends Neurosci. 2013 May;36(5):305-12
pubmed: 23384445
Sleep. 1991 Aug;14(4):325-30
pubmed: 1947596
Sci Rep. 2022 Feb 10;12(1):2265
pubmed: 35145140
J Biotechnol. 2017 Nov 10;261:169-176
pubmed: 28648396
Nat Rev Neurosci. 2010 Feb;11(2):114-26
pubmed: 20046194
PLoS One. 2019 Oct 7;14(10):e0222394
pubmed: 31589627
Nat Methods. 2016 Jul;13(7):581-3
pubmed: 27214047
Behav Sleep Med. 2008;6(1):32-54
pubmed: 18412036
J Clin Neurol. 2014 Jul;10(3):210-5
pubmed: 25045373
Sleep Med. 2020 Feb;66:148-158
pubmed: 31877506
Brain Behav Immun. 2015 Aug;48:186-94
pubmed: 25882912
Clocks Sleep. 2021 Jul 01;3(3):387-397
pubmed: 34287254
Gut. 2011 Mar;60(3):307-17
pubmed: 20966022
J Cogn Neurosci. 2007 May;19(5):817-29
pubmed: 17488206
Front Endocrinol (Lausanne). 2020 Jan 31;11:25
pubmed: 32082260
Behav Brain Res. 2007 Jun 4;180(1):48-61
pubmed: 17400305
Sleep Med. 2015 Mar;16(3):364-71
pubmed: 25620200
Int Rev Neurobiol. 2016;131:227-246
pubmed: 27793221
Sleep. 2000 Feb 1;23(1):87-95
pubmed: 10678469
Front Neurol. 2020 Feb 25;11:137
pubmed: 32161568
Front Aging Neurosci. 2015 Sep 07;7:166
pubmed: 26441633
Nature. 2012 May 09;486(7402):222-7
pubmed: 22699611
Front Neurol. 2022 Feb 17;13:834403
pubmed: 35250836
Clin Interv Aging. 2014 Dec 19;10:37-48
pubmed: 25565785
Mol Metab. 2016 Oct 24;5(12):1175-1186
pubmed: 27900260
Lancet Neurol. 2015 May;14(5):547-58
pubmed: 25895933
Dementia. 1994 Sep-Oct;5(5):266-81
pubmed: 7951684
Gut. 2018 Dec;67(12):2213-2222
pubmed: 30194220
Am J Epidemiol. 2000 Apr 1;151(7):676-88
pubmed: 10752795
Behav Res Ther. 2003 Apr;41(4):427-45
pubmed: 12643966
Sleep. 2016 Dec 01;39(12):2101-2111
pubmed: 27634805
J Sleep Res. 2020 Dec;29(6):e12929
pubmed: 31651070
Behav Sleep Med. 2019 Sep-Oct;17(5):552-560
pubmed: 29368954
Nat Methods. 2013 Dec;10(12):1200-2
pubmed: 24076764
Comp Med. 2010 Oct;60(5):336-47
pubmed: 21262117
Health Psychol. 2013 Mar;32(3):311-9
pubmed: 22746259
J Am Geriatr Soc. 1999 Oct;47(10):1249-54
pubmed: 10522960
Sci Rep. 2017 Sep 5;7(1):10411
pubmed: 28874832
Sleep Sci. 2019 Apr-Jun;12(2):88-93
pubmed: 31879540
Neuron. 2004 Sep 30;44(1):121-33
pubmed: 15450165
Microorganisms. 2020 Apr 15;8(4):
pubmed: 32326636
Int J Psychophysiol. 1989 Sep;8(1):43-7
pubmed: 2584082
Physiol Rev. 2019 Oct 1;99(4):1877-2013
pubmed: 31460832
Nature. 2012 Aug 30;488(7413):621-6
pubmed: 22914093
Brain Behav Immun. 2010 Jan;24(1):9-16
pubmed: 19481599
Assessment. 2016 Apr;23(2):163-72
pubmed: 25882162
Nutrients. 2019 Nov 07;11(11):
pubmed: 31703257
Sleep Med. 2001 Jul;2(4):297-307
pubmed: 11438246
Behav Sleep Med. 2017 Sep-Oct;15(5):361-376
pubmed: 27148632
Sci Transl Med. 2009 Nov 11;1(6):6ra14
pubmed: 20368178
Sleep Med. 2017 Oct;38:104-107
pubmed: 29031742
Learn Mem. 2004 Nov-Dec;11(6):714-9
pubmed: 15576889
Nat Rev Gastroenterol Hepatol. 2009 May;6(5):306-14
pubmed: 19404271
Science. 2016 Apr 29;352(6285):560-4
pubmed: 27126039
Front Psychiatry. 2018 Dec 05;9:669
pubmed: 30568608
Front Microbiol. 2019 Aug 13;10:1770
pubmed: 31456757
BMC Microbiol. 2019 Oct 28;19(1):236
pubmed: 31660868
Front Neurol. 2012 Jul 11;3:109
pubmed: 22798956
J Clin Epidemiol. 1994 Sep;47(9):1061-7
pubmed: 7730909
Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1564-E1571
pubmed: 28179566
Nature. 2004 Jul 1;430(6995):78-81
pubmed: 15184907
J Sleep Res. 2006 Sep;15(3):250-5
pubmed: 16911026