Meta-analysis of molecular imaging of translocator protein in major depression.

depression meta-analysis molecular imaging neuroinflammation positron emission tomography translocator protein

Journal

Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914

Informations de publication

Date de publication:
2022
Historique:
received: 29 06 2022
accepted: 01 09 2022
entrez: 13 10 2022
pubmed: 14 10 2022
medline: 14 10 2022
Statut: epublish

Résumé

Molecular neuroimaging studies provide mounting evidence that neuroinflammation plays a contributory role in the pathogenesis of major depressive disorder (MDD). This has been the focus of a number of positron emission tomography (PET) studies of the 17-kDa translocator protein (TSPO), which is expressed by microglia and serves as a marker of neuroinflammation. In this meta-analysis, we compiled and analyzed all available molecular imaging studies comparing cerebral TSPO binding in MDD patients with healthy controls. Our systematic literature search yielded eight PET studies encompassing 238 MDD patients and 164 healthy subjects. The meta-analysis revealed relatively increased TSPO binding in several cortical regions (anterior cingulate cortex: Hedges'

Identifiants

DOI: 10.3389/fnmol.2022.981442 PMID: 36226319 PMC: PMC9549359
pubmed: 36226319
doi: 10.3389/fnmol.2022.981442
pmc: PMC9549359
doi:

Types de publication

Systematic Review

Langues

eng

Pagination

981442

Informations de copyright

Copyright © 2022 Eggerstorfer, Kim, Cumming, Lanzenberger and Gryglewski.

Déclaration de conflit d'intérêts

RL received travel grants and/or conference speaker honoraria within the last 3 years from Bruker BioSpin MR, Heel, and support from Siemens Healthcare regarding clinical research using PET/MR. He has been a shareholder of the start-up company BM Health GmbH since 2019. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Benjamin Eggerstorfer (B)

Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria.

Jong-Hoon Kim (JH)

Department of Psychiatry, Gachon University College of Medicine, Gil Medical Center, Neuroscience Research Institute, GAIHST, Gachon University, Incheon, South Korea.

Paul Cumming (P)

Department of Nuclear Medicine, Inselspital, Bern University, Bern, Switzerland.
School of Psychology and Counselling, Queensland University of Technology, Brisbane, QLD, Australia.

Rupert Lanzenberger (R)

Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria.

Gregor Gryglewski (G)

Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria.

Classifications MeSH