Projections from the five divisions of the orbital cortex to the thalamus in the rat.
behavioral flexibility
cognition
medial prefrontal cortex
mediodorsal nucleus
nucleus reuniens
paratenial nucleus
reversal learning
Journal
The Journal of comparative neurology
ISSN: 1096-9861
Titre abrégé: J Comp Neurol
Pays: United States
ID NLM: 0406041
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
revised:
08
09
2022
received:
23
06
2022
accepted:
14
09
2022
pmc-release:
01
02
2024
pubmed:
14
10
2022
medline:
20
12
2022
entrez:
13
10
2022
Statut:
ppublish
Résumé
The orbital cortex (ORB) of the rat consists of five divisions: the medial (MO), ventral (VO), ventrolateral (VLO), lateral (LO), and dorsolateral (DLO) orbital cortices. No previous report has comprehensively examined and compared projections from each division of the ORB to the thalamus. Using the anterograde anatomical tracer, Phaseolus vulgaris leucoagglutinin, we describe the efferent projections from the five divisions of the ORB to the thalamus in the rat. We demonstrated that, with some overlap, each division of the ORB distributed in a distinct (and unique) manner to nuclei of the thalamus. Overall, ORB projected to a relatively restricted number of sites in the thalamus, and strikingly distributed entirely to structures of the medial/midline thalamus, while completely avoiding lateral regions or principal nuclei of the thalamus. The main termination sites in the thalamus were the paratenial nucleus (PT) and nucleus reuniens (RE) of the midline thalamus, the medial (MDm) and central (MDc) divisions of the mediodorsal nucleus, the intermediodorsal nucleus, the central lateral, paracentral, and central medial nuclei of the rostral intralaminar complex and the submedial nucleus (SM). With some exceptions, medial divisions of the ORB (MO, VO) mainly targeted "limbic-associated" nuclei such as PT, RE, and MDm, whereas lateral division (VLO, LO, DLO) primarily distributed to "sensorimotor-associated" nuclei including MDc, SM, and the rostral intralaminar complex. As discussed herein, the medial/midline thalamus may represent an important link (or bridge) between the orbital cortex and the hippocampus and between the ORB and medial prefrontal cortex. In summary, the present results demonstrate that each division of the orbital cortex projects in a distinct manner to nuclei of the thalamus which suggests unique functions for each division of the orbital cortex.
Identifiants
pubmed: 36226328
doi: 10.1002/cne.25419
pmc: PMC9772129
mid: NIHMS1837257
doi:
Substances chimiques
Phytohemagglutinins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
217-237Subventions
Organisme : NINDS NIH HHS
ID : R15 NS108259
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS119847
Pays : United States
Informations de copyright
© 2022 Wiley Periodicals LLC.
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