Repeated exposure to fractional CO
ablative fractional laser
line-field confocal optical coherence tomography
photodamage
photoprevention
squamous cell carcinoma
ultraviolet radiation
Journal
Lasers in surgery and medicine
ISSN: 1096-9101
Titre abrégé: Lasers Surg Med
Pays: United States
ID NLM: 8007168
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
revised:
26
09
2022
received:
18
08
2022
accepted:
26
09
2022
pubmed:
15
10
2022
medline:
2
2
2023
entrez:
14
10
2022
Statut:
ppublish
Résumé
Ablative fractional laser (AFL) is a well-established modality for treating ultraviolet radiation (UVR)-induced skin photodamage. We aimed to investigate the potential of AFL to delay squamous cell carcinoma (SCC) formation and prevent photodamage in a preclinical UVR-induced SCC model. Hairless C3.Cg-Hr Repeated AFL treatments delayed SCC tumor development compared to UVR control mice by 12, 19, and 30 days for first, second, and third tumors, respectively (p ≤ 0.0017). Compared to UVR controls, AFL prevented photodamage both clinically and subclinically, based on LC-OCT and histology. In the epidermal layer, AFL imparted photopreventative effects including reduced dyspigmentation and keratinocyte dysplasia (1 vs. 2.5, p = 0.0079) and partial normalization of the epidermal thickness (p < 0.0001). In the dermis, AFL led to twofold greater skin tightness (p = 0.0079), improved dermo-fiber structure, and dermal thickness (p = 0.0011). In conclusion, repeated AFL treatments of UVR-exposed skin significantly delayed SCC tumor formation and prevented clinical and imaging-assessed subclinical signs of photodamage, indicating a potential for AFL in prevention strategies for SCC and photodamage in high-risk populations.
Identifiants
pubmed: 36229986
doi: 10.1002/lsm.23613
pmc: PMC10092156
doi:
Substances chimiques
Carbon Dioxide
142M471B3J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
73-81Informations de copyright
© 2022 The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals LLC.
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