High Blood Concentration of Leukocyte-Derived Extracellular Vesicles Is Predictive of Favorable Clinical Outcomes in Patients with Pancreatic Cancer: Results from a Multicenter Prospective Study.
extracellular vesicles
leukocytes
pancreatic cancer
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
29 Sep 2022
29 Sep 2022
Historique:
received:
06
09
2022
revised:
23
09
2022
accepted:
26
09
2022
entrez:
14
10
2022
pubmed:
15
10
2022
medline:
15
10
2022
Statut:
epublish
Résumé
Pancreatic cancer (PC) is one of the leading causes of cancer-related death worldwide. Identification of novel tumor biomarkers is highly advocated in PC to optimize personalized treatment algorithms. Blood-circulating extracellular vesicles hold promise for liquid biopsy application in cancer. We used an optimized flow cytometry protocol to study leukocyte-derived EVs (CD45+) and PD-L1+ EVs in blood from 56 pancreatic cancer patients and 48 healthy controls (HCs). Our results show that PC patients presented higher blood levels of total EVs (
Identifiants
pubmed: 36230671
pii: cancers14194748
doi: 10.3390/cancers14194748
pmc: PMC9562679
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Italian Ministry of University and Research (MIUR), "Progetti di Ricerca di Interesse Nazionale" (PRIN)
ID : 2017EKMFTN_005
Organisme : University "G.d'Annunzio" of Chieti-Pescara, "Search for Excellence 2020" to P.S."
ID : CUP D59C20000680005
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