Heterogeneity and Functions of Tumor-Infiltrating Antibody Secreting Cells: Lessons from Breast, Ovarian, and Other Solid Cancers.
antibodies
antibody-secreting cells
breast cancer
heterogeneity
ovarian cancer
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
30 Sep 2022
30 Sep 2022
Historique:
received:
22
08
2022
revised:
26
09
2022
accepted:
27
09
2022
entrez:
14
10
2022
pubmed:
15
10
2022
medline:
15
10
2022
Statut:
epublish
Résumé
Neglected for a long time in cancer, B cells and ASCs have recently emerged as critical actors in the tumor microenvironment, with important roles in shaping the antitumor immune response. ASCs indeed exert a major influence on tumor growth, patient survival, and response to therapies. The mechanisms underlying their pro- vs. anti-tumor roles are beginning to be elucidated, revealing the contributions of their secreted antibodies as well as of their emerging noncanonical functions. Here, concentrating mostly on ovarian and breast cancers, we summarize the current knowledge on the heterogeneity of tumor-infiltrating ASCs, we discuss their possible local or systemic origin in relation to their immunoglobulin repertoire, and we review the different mechanisms by which antibody (Ab) subclasses and isoforms differentially impact tumor cells and anti-tumor immunity. We also discuss the emerging roles of cytokines and other immune modulators produced by ASCs in cancer. Finally, we propose strategies to manipulate the tumor ASC compartment to improve cancer therapies.
Identifiants
pubmed: 36230721
pii: cancers14194800
doi: 10.3390/cancers14194800
pmc: PMC9563085
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-18-RHUS-0012
Organisme : French National Cancer Institute
ID : INCa PRT-K 2016
Organisme : Ligue Nationale Contre le Cancer
ID : Comités Rhône et Savoie
Organisme : Fondation ARC pour la Recherche sur le Cancer
ID : PJA 20191209557
Organisme : SIRIC LYriCAN
ID : INCa-DGOS-Inserm_12563
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