COVID-19 Pathology in the Lung, Kidney, Heart and Brain: The Different Roles of T-Cells, Macrophages, and Microthrombosis.
COVID-19
SARS-CoV-2
brain
elderly
heart
inflammation
kidney
lung
neuropathology
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
04 10 2022
04 10 2022
Historique:
received:
26
08
2022
revised:
28
09
2022
accepted:
29
09
2022
entrez:
14
10
2022
pubmed:
15
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
Here, we aim to describe COVID-19 pathology across different tissues to clarify the disease's pathophysiology. Lungs, kidneys, hearts, and brains from nine COVID-19 autopsies were compared by using antibodies against SARS-CoV-2, macrophages-microglia, T-lymphocytes, B-lymphocytes, and activated platelets. Alzheimer's Disease pathology was also assessed. PCR techniques were used to verify the presence of viral RNA. COVID-19 cases had a short clinical course (0-32 days) and their mean age was 77.4 y/o. Hypoxic changes and inflammatory infiltrates were present across all tissues. The lymphocytic component in the lungs and kidneys was predominant over that of other tissues (
Identifiants
pubmed: 36231087
pii: cells11193124
doi: 10.3390/cells11193124
pmc: PMC9563269
pii:
doi:
Substances chimiques
Antigens, Viral
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Diabetes Metab Syndr. 2021 May-Jun;15(3):869-875
pubmed: 33892403
Acta Neuropathol Commun. 2020 Aug 26;8(1):147
pubmed: 32847628
Histopathology. 2020 Aug;77(2):186-197
pubmed: 32443177
Acta Neuropathol. 2020 Jul;140(1):1-6
pubmed: 32449057
Mod Pathol. 2021 Sep;34(9):1614-1633
pubmed: 34031537
Lancet. 2020 Aug 1;396(10247):320-332
pubmed: 32682491
Ann Med Surg (Lond). 2020 Dec;60:526-530
pubmed: 33200030
Cleve Clin J Med. 2020 Oct 1;87(10):619-631
pubmed: 33004323
World J Nephrol. 2015 Feb 6;4(1):74-82
pubmed: 25664248
J Am Soc Nephrol. 2020 Aug;31(8):1683-1687
pubmed: 32371536
Turk J Gastroenterol. 2022 Feb;33(2):145-152
pubmed: 35115295
J Am Soc Nephrol. 2020 Sep;31(9):2158-2167
pubmed: 32727719
Cardiovasc Pathol. 2021 Sep-Oct;54:107370
pubmed: 34273507
J Neuropathol Exp Neurol. 2019 Nov 1;78(11):1059-1065
pubmed: 31559425
Am J Emerg Med. 2021 Jan;39:213-218
pubmed: 33036855
Neuropathol Appl Neurobiol. 2021 Feb;47(1):3-16
pubmed: 32935873
JAMA Cardiol. 2020 Jul 1;5(7):811-818
pubmed: 32219356
Cell. 2020 Oct 1;183(1):16-27.e1
pubmed: 32882182
EClinicalMedicine. 2020 Sep;26:100490
pubmed: 32838241
Aging (Albany NY). 2020 May 29;12(10):9959-9981
pubmed: 32470948
Brain Pathol. 2021 Sep;31(5):e12997
pubmed: 34145669
Lancet. 2020 May 2;395(10234):1417-1418
pubmed: 32325026
Liver Int. 2020 Sep;40(9):2095-2103
pubmed: 32239796
Front Immunol. 2020 Jun 16;11:1446
pubmed: 32612617
N Engl J Med. 2020 Jul 9;383(2):120-128
pubmed: 32437596
Int J Legal Med. 2020 Jul;134(4):1275-1284
pubmed: 32500199
Intern Emerg Med. 2021 Aug;16(5):1123-1129
pubmed: 33484452
Brain Pathol. 2020 Nov;30(6):1012-1016
pubmed: 32762083
Chest. 2021 Jan;159(1):73-84
pubmed: 33038391
Lancet. 2020 Jun 20;395(10241):e109
pubmed: 32505222
Mod Pathol. 2020 Nov;33(11):2156-2168
pubmed: 32879413
Adv Virus Res. 2018;100:163-188
pubmed: 29551135
EClinicalMedicine. 2021 Sep;39:101044
pubmed: 34316551
Science. 2020 Jul 17;369(6501):256-257
pubmed: 32675364
Eur Heart J Cardiovasc Imaging. 2020 Jul 1;21(7):776
pubmed: 32338706
Histopathology. 2020 Aug;77(2):198-209
pubmed: 32364264
Genome Med. 2021 Jul 19;13(1):118
pubmed: 34281603
Eur Rev Med Pharmacol Sci. 2021 Sep;25(17):5561-5577
pubmed: 34533807
JAMA Psychiatry. 2021 Jun 1;78(6):682-683
pubmed: 33769431
Circ Res. 2020 Jul 31;127(4):571-587
pubmed: 32586214
ACS Chem Neurosci. 2020 Apr 1;11(7):995-998
pubmed: 32167747
Cell Discov. 2021 Mar 23;7(1):17
pubmed: 33758165
Lancet Microbe. 2020 Oct;1(6):e245-e253
pubmed: 32844161
Mod Pathol. 2021 Aug;34(8):1456-1467
pubmed: 33795830
JAMA. 2020 Jun 23;323(24):2518-2520
pubmed: 32437497
Neuropathol Appl Neurobiol. 2021 Apr;47(3):454-459
pubmed: 33249605
Nat Neurosci. 2021 Feb;24(2):168-175
pubmed: 33257876
World J Gastroenterol. 2020 Jun 14;26(22):2987-2999
pubmed: 32587443
J Thromb Haemost. 2020 Sep;18(9):2103-2109
pubmed: 32558075
Int J Infect Dis. 2020 May;94:44-48
pubmed: 32171952
Cardiovasc Pathol. 2020 Nov - Dec;49:107263
pubmed: 32784110
R I Med J (2013). 2020 Sep 4;103(8):24-28
pubmed: 32900008
Hum Pathol. 2020 Nov;105:74-83
pubmed: 32750378
Clin Res Cardiol. 2021 Nov;110(11):1822-1831
pubmed: 34282465
J Vis Exp. 2020 Jun 3;(160):
pubmed: 32568219
Intensive Care Med. 2020 Jun;46(6):1114-1116
pubmed: 32236644
Brain. 2022 Jul 29;145(7):2555-2568
pubmed: 35788639
JAMA Cardiol. 2020 Nov 1;5(11):1281-1285
pubmed: 32730555
Nat Rev Nephrol. 2021 Dec;17(12):792-793
pubmed: 34504319
Eur J Clin Microbiol Infect Dis. 2021 May;40(5):905-919
pubmed: 33389262
Acta Neuropathol. 2020 Sep;140(3):397-400
pubmed: 32638079
J Clin Pathol. 2021 Feb;74(2):76-83
pubmed: 32817204
Kidney Int. 2020 Jul;98(1):219-227
pubmed: 32327202
BMJ Case Rep. 2020 Aug 18;13(8):
pubmed: 32816925
Lancet Respir Med. 2020 Jul;8(7):681-686
pubmed: 32473124
Clin Rheumatol. 2020 Jul;39(7):2085-2094
pubmed: 32474885
J Proteome Res. 2021 Jan 1;20(1):49-59
pubmed: 33347311
Nat Rev Microbiol. 2021 Mar;19(3):141-154
pubmed: 33024307
J Stroke Cerebrovasc Dis. 2020 Dec;29(12):105307
pubmed: 32992201
Lancet Neurol. 2020 Nov;19(11):919-929
pubmed: 33031735
Cells. 2021 Jul 27;10(8):
pubmed: 34440669
N Engl J Med. 2021 Feb 4;384(5):481-483
pubmed: 33378608
Eur Heart J. 2020 Oct 14;41(39):3827-3835
pubmed: 32968776
Neurol Sci. 2020 Oct;41(10):2657-2669
pubmed: 32725449
Lancet Microbe. 2020 Nov;1(7):e290-e299
pubmed: 33015653
N Engl J Med. 2020 Sep 3;383(10):989-992
pubmed: 32530583
Signal Transduct Target Ther. 2020 Dec 4;5(1):283
pubmed: 33277466
Pathobiology. 2021;88(1):56-68
pubmed: 32942274
J Infect Dis. 2020 Nov 9;222(11):1807-1815
pubmed: 32914853
Biomed Pharmacother. 2020 Nov;131:110678
pubmed: 32861070
Acta Neuropathol. 2020 Oct;140(4):583-586
pubmed: 32851506
J Intern Med. 2021 Sep;290(3):655-665
pubmed: 33872433
Acta Neuropathol. 2016 Feb;131(2):159-184
pubmed: 26659576
Acta Neuropathol. 2012 Jan;123(1):1-11
pubmed: 22101365
Nat Med. 2021 Apr;27(4):601-615
pubmed: 33753937
Brain Behav Immun. 2021 Oct;97:13-21
pubmed: 34022369
J Gerontol A Biol Sci Med Sci. 2020 Sep 16;75(9):e34-e41
pubmed: 32544216
Respir Res. 2020 Aug 27;21(1):224
pubmed: 32854739
Forensic Sci Med Pathol. 2021 Jun;17(2):262-270
pubmed: 33582936