Age-Related Low Bone Mineral Density in C57BL/6 Mice Is Reflective of Aberrant Bone Morphogenetic Protein-2 Signaling Observed in Human Patients Diagnosed with Osteoporosis.
BMP-2
C2C12 cells
C57BL/6 mice
CK2
CK2.3
osteoblasts
osteoclasts
osteoporosis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Sep 2022
23 Sep 2022
Historique:
received:
14
08
2022
revised:
11
09
2022
accepted:
21
09
2022
entrez:
14
10
2022
pubmed:
15
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
Osteoporosis (OP) is a bone disorder characterized by decreased bone mineral density (BMD). Bone Morphogenetic Protein-2 (BMP-2) injections are used to promote bone formation in OP patients. However, patients are unresponsive to BMP-2 while displaying an upregulation of BMP Receptor Type 1a (BMPRIa) and protein kinase CK2α (CK2α). A synthetically produced peptide named casein kinase 2.3 (CK2.3) utilizes the BMP-signaling pathway as it enhances osteogenesis of primary osteoblasts isolated from OP patients, whereas BMP-2 does not. Although shown in OP patients, there is currently no reliable mouse model to study BMP-2 and CK2.3 signaling. In this publication, we show that BMPRIa was required for CK2.3-mediated osteogenesis in C2C12 cells with a CRISPR-Cas9-mediated gene knockout for
Identifiants
pubmed: 36232525
pii: ijms231911205
doi: 10.3390/ijms231911205
pmc: PMC9570292
pii:
doi:
Substances chimiques
Bone Morphogenetic Protein 2
0
Casein Kinase II
EC 2.7.11.1
Bone Morphogenetic Protein Receptors
EC 2.7.11.30
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Nathan Shock Center
ID : Pilot Award
Organisme : NIAMS NIH HHS
ID : 1R21AR076689-01A1
Pays : United States
Organisme : National Institute of Health's General Medical Sciences
ID : P20GM103446
Organisme : National Institute of Health's General Medical Sciences
ID : P20GM139760
Organisme : NIGMS NIH HHS
ID : P20 GM139760
Pays : United States
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