The Plasma Oxylipin Signature Provides a Deep Phenotyping of Metabolic Syndrome Complementary to the Clinical Criteria.
lipid mediators
lipidomics
metabolic phenotyping
metabolic syndrome
oxylipins
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Oct 2022
02 Oct 2022
Historique:
received:
19
08
2022
revised:
23
09
2022
accepted:
24
09
2022
entrez:
14
10
2022
pubmed:
15
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
Metabolic syndrome (MetS) is a complex condition encompassing a constellation of cardiometabolic abnormalities. Oxylipins are a superfamily of lipid mediators regulating many cardiometabolic functions. Plasma oxylipin signature could provide a new clinical tool to enhance the phenotyping of MetS pathophysiology. A high-throughput validated mass spectrometry method, allowing for the quantitative profiling of over 130 oxylipins, was applied to identify and validate the oxylipin signature of MetS in two independent nested case/control studies involving 476 participants. We identified an oxylipin signature of MetS (coined OxyScore), including 23 oxylipins and having high performances in classification and replicability (cross-validated AUC
Identifiants
pubmed: 36232991
pii: ijms231911688
doi: 10.3390/ijms231911688
pmc: PMC9570185
pii:
doi:
Substances chimiques
Oxylipins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-16-HDHL-0004-01/02
Organisme : Federal Ministry of Education and Research
ID : 01EA1702
Organisme : Danish Agency for Science, Technology and Innovation
ID : 4203 - 00006B
Organisme : National Science Center
ID : ERAH.E220.18.001
Organisme : Population Health Research Institute
ID : 290/W-PURE/2008/0
Organisme : United States Department of Agriculture
ID : 2032-51530-025-00D
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