Aplastic Anemia as a Roadmap for Bone Marrow Failure: An Overview and a Clinical Workflow.
aplastic anemia
bone marrow failure
bone marrow immune-microenvironment
cytopenia
hematopoietic stem cells
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Oct 2022
04 Oct 2022
Historique:
received:
10
09
2022
revised:
27
09
2022
accepted:
28
09
2022
entrez:
14
10
2022
pubmed:
15
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
In recent years, it has become increasingly apparent that bone marrow (BM) failures and myeloid malignancy predisposition syndromes are characterized by a wide phenotypic spectrum and that these diseases must be considered in the differential diagnosis of children and adults with unexplained hematopoiesis defects. Clinically, hypocellular BM failure still represents a challenge in pathobiology-guided treatment. There are three fundamental topics that emerged from our review of the existing data. An exogenous stressor, an immune defect, and a constitutional genetic defect fuel a vicious cycle of hematopoietic stem cells, immune niches, and stroma compartments. A wide phenotypic spectrum exists for inherited and acquired BM failures and predispositions to myeloid malignancies. In order to effectively manage patients, it is crucial to establish the right diagnosis. New theragnostic windows can be revealed by exploring BM failure pathomechanisms.
Identifiants
pubmed: 36233062
pii: ijms231911765
doi: 10.3390/ijms231911765
pmc: PMC9569739
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Haematologica. 2014 Oct;99(10):1574-81
pubmed: 25085353
Haematologica. 2009 May;94(5):712-9
pubmed: 19336743
Cancers (Basel). 2021 May 17;13(10):
pubmed: 34067631
Hematology Am Soc Hematol Educ Program. 2013;2013:76-81
pubmed: 24319166
Blood. 2017 May 25;129(21):2908-2916
pubmed: 28232583
Blood. 2017 Mar 16;129(11):1428-1436
pubmed: 28096088
Haematologica. 2018 Feb;103(2):212-220
pubmed: 29170252
Blood. 2007 Sep 1;110(5):1603-6
pubmed: 17463169
Front Med (Lausanne). 2021 Jan 20;7:625176
pubmed: 33553217
Haematologica. 2018 May;103(5):759-769
pubmed: 29419434
N Engl J Med. 2022 Jan 6;386(1):11-23
pubmed: 34986284
Am J Clin Pathol. 2019 Aug 1;152(3):258-276
pubmed: 31309983
Blood. 2011 Dec 15;118(25):6601-9
pubmed: 21963603
Blood. 2014 Feb 6;123(6):809-21
pubmed: 24227816
Int J Hematol. 2015 Jun;101(6):527-35
pubmed: 25837779
Blood. 2007 Apr 1;109(7):2794-6
pubmed: 17110459
Ann Hematol. 2005 Sep;84(9):572-7
pubmed: 15815907
Am J Hematol. 2018 May;93(5):643-648
pubmed: 29498107
Haematologica. 2014 Dec;99(12):1784-91
pubmed: 25193958
Haematologica. 2016 Nov;101(11):1343-1350
pubmed: 27418648
Haematologica. 2017 Oct;102(10):e382-e383
pubmed: 28705902
Blood Adv. 2018 May 8;2(9):1000-1012
pubmed: 29720492
Haematologica. 2009 Dec;94(12):1743-7
pubmed: 19586939
J Clin Exp Hematop. 2018;58(2):68-86
pubmed: 29998978
Eur J Haematol Suppl. 1996;60:23-30
pubmed: 8987237
Blood. 2016 Jul 21;128(3):337-47
pubmed: 27121470
Blood. 2011 Jun 23;117(25):6786-92
pubmed: 21460245
Blood. 2007 Dec 1;110(12):4123-8
pubmed: 17702897
Blood. 2016 Apr 7;127(14):1770-9
pubmed: 26903545
Exp Hematol. 2017 Jan;45:56-63
pubmed: 27693387
Blood Adv. 2018 Feb 27;2(4):390-400
pubmed: 29472446
Lancet. 2004 Jul 24-30;364(9431):355-64
pubmed: 15276395
Haematologica. 2015 May;100(5):696-702
pubmed: 25616576
Int J Mol Sci. 2015 Jan 05;16(1):966-89
pubmed: 25569081
Haematologica. 2019 Nov;104(11):e494-e496
pubmed: 30890599
Haematologica. 2017 Oct;102(10):1683-1690
pubmed: 28751565
J Immunol. 2002 Jun 15;168(12):5984-8
pubmed: 12055203
Blood. 2011 Aug 25;118(8):2351-7
pubmed: 21518925
Oncotarget. 2020 Jan 28;11(4):480-487
pubmed: 32064051
Oncologist. 2020 Feb;25(2):112-118
pubmed: 32043788
Exp Hematol. 2007 Jan;35(1):13-20
pubmed: 17198869
Cochrane Database Syst Rev. 2013 Jul 23;(7):CD006407
pubmed: 23881658
Pediatr Dev Pathol. 2019 Jul-Aug;22(4):315-328
pubmed: 30600763
J Hematol Oncol. 2016 Mar 31;9:32
pubmed: 27036622
Cancers (Basel). 2021 Jul 08;13(14):
pubmed: 34298648
JAMA. 2015 Feb 10;313(6):594-602
pubmed: 25668263
Acta Haematol. 2020;143(1):33-39
pubmed: 31216534
Blood. 2016 Mar 17;127(11):1387-97; quiz 1518
pubmed: 26702063
Blood. 2002 Jul 1;100(1):178-83
pubmed: 12070025
Eur J Haematol. 1997 Apr;58(4):265-72
pubmed: 9186538
Br J Haematol. 2004 Sep;126(5):682-5
pubmed: 15327519
Front Oncol. 2020 Oct 29;10:599098
pubmed: 33194767
Mol Cell Biol. 2018 May 29;38(12):
pubmed: 29581184
N Engl J Med. 2006 Sep 21;355(12):1233-43
pubmed: 16990386
Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):143-152
pubmed: 34889408
Blood. 2011 Apr 28;117(17):4434-41
pubmed: 21233311
Ann Hematol. 2018 Jul;97(7):1251-1258
pubmed: 29589107
Nat Rev Cancer. 2018 Mar;18(3):168-185
pubmed: 29376519
Pediatr Blood Cancer. 2020 Oct;67(10):e28444
pubmed: 32776425
Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):153-156
pubmed: 34889379
Blood. 2007 Jun 15;109(12):5234-7
pubmed: 17311987
Pediatr Blood Cancer. 2014 May;61(5):869-74
pubmed: 24285674
Blood. 2012 Jun 7;119(23):5391-6
pubmed: 22544699
Haematologica. 2012 Aug;97(8):1142-8
pubmed: 22315497
N Engl J Med. 2018 Oct 25;379(17):1643-1656
pubmed: 30354958
Blood. 2006 Feb 1;107(3):1184-91
pubmed: 16195329
J Clin Invest. 2022 Aug 1;132(15):
pubmed: 35912855
Blood. 2003 Aug 15;102(4):1211-6
pubmed: 12676778
Bone Marrow Transplant. 2017 Jan;52(1):47-52
pubmed: 27668766
Haematologica. 2017 Jul;102(7):1291-1298
pubmed: 28341733
Immunol Invest. 2014;43(5):491-503
pubmed: 24661133
Semin Oncol. 2016 Oct;43(5):598-608
pubmed: 27899193
Br J Haematol. 2015 May;169(4):565-73
pubmed: 25683884
Br J Haematol. 2009 Sep;146(5):538-45
pubmed: 19594748
Biol Blood Marrow Transplant. 2017 Mar;23(3):498-504
pubmed: 28013015
Bone Marrow Transplant. 2016 Feb;51(2):288-90
pubmed: 26437067
Haematologica. 2007 Jan;92(1):11-8
pubmed: 17229630
EMBO J. 2016 May 2;35(9):909-23
pubmed: 27037238
Cancers (Basel). 2019 Aug 29;11(9):
pubmed: 31470608
Leukemia. 2006 Mar;20(3):458-62
pubmed: 16437138
N Engl J Med. 1993 Oct 14;329(16):1152-7
pubmed: 8377778
N Engl J Med. 2005 Apr 7;352(14):1413-24
pubmed: 15814878
Int J Mol Sci. 2021 Jan 12;22(2):
pubmed: 33445786
Haematologica. 2016 Jul;101(7):884-90
pubmed: 27056924
Bone Marrow Transplant. 2018 Jan;53(1):105-107
pubmed: 29131151
Nat Commun. 2017 Nov 16;8(1):1557
pubmed: 29146900
Blood. 2017 Jan 19;129(3):388-392
pubmed: 27903525
Ann Med. 2022 Dec;54(1):2431-2439
pubmed: 36066098
Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):134-142
pubmed: 34889426
Haematologica. 2014 Nov;99(11):1686-96
pubmed: 25150255
Haematologica. 2009 Dec;94(12):1661-8
pubmed: 19996117
Int J Mol Sci. 2020 Apr 27;21(9):
pubmed: 32349317
Eur J Haematol. 2015 Sep;95(3):230-8
pubmed: 25404431
Am J Hum Genet. 2019 Aug 1;105(2):237-257
pubmed: 31374202
Hematol Oncol Clin North Am. 2009 Apr;23(2):193-214
pubmed: 19327579
Clin Exp Immunol. 2019 Jul;197(1):24-35
pubmed: 30830965
Blood. 2016 Sep 1;128(9):1193-205
pubmed: 27281795
Haematologica. 2016 May;101(5):644-52
pubmed: 26858357
Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):83-89
pubmed: 27913466
Am J Hematol. 2018 May;93(5):635-642
pubmed: 29377260
Clin Exp Immunol. 2015 Jun;180(3):361-70
pubmed: 25683099
J Clin Med. 2021 Jun 29;10(13):
pubmed: 34209964
J Oncol. 2020 May 18;2020:6820241
pubmed: 32508920
J Pediatr. 2008 Dec;153(6):814-9
pubmed: 18672253
J Biol Chem. 2002 Mar 8;277(10):7726-35
pubmed: 11773065
Blood. 2012 Aug 23;120(8):1624-32
pubmed: 22797698
Haematologica. 2006 May;91(5):656-8
pubmed: 16627250
Blood. 2006 Oct 15;108(8):2509-19
pubmed: 16778145
Ann Intern Med. 1997 Jan 15;126(2):107-15
pubmed: 9005744
Am J Hematol. 2004 May;76(1):92-3
pubmed: 15114608
Br J Haematol. 2015 Nov;171(4):585-94
pubmed: 26223288
Am J Pathol. 2006 Jan;168(1):123-30
pubmed: 16400015
Pediatr Blood Cancer. 2004 Oct;43(5):545-51
pubmed: 15382271
N Engl J Med. 2015 Jul 2;373(1):35-47
pubmed: 26132940
Exp Hematol. 2005 Jul;33(7):819-27
pubmed: 15963858
Blood. 2017 Jun 22;129(25):3371-3378
pubmed: 28424163
N Engl J Med. 2011 Aug 4;365(5):430-8
pubmed: 21812672
Br J Haematol. 2008 Jan;140(2):197-205
pubmed: 18173756
Biomedicines. 2021 Apr 02;9(4):
pubmed: 33918146