Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models.
Hargreaves plantar test
alpha-2-delta-1 subunit
dark/light box test
fibromyalgia
forced swimming test
gliosis
immunohistochemistry
nociplastic pain
reserpine
sigma-1 receptor
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Oct 2022
08 Oct 2022
Historique:
received:
10
09
2022
revised:
05
10
2022
accepted:
06
10
2022
entrez:
14
10
2022
pubmed:
15
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
Sigma-1 receptor (σ1R) ligands have been shown to be effective at relieving neuropathic and inflammatory pain, but have not yet been tested in experimental models of fibromyalgia. The objective of this study was to evaluate the effect of a σ1R antagonist (BD1063) compared to pregabalin. ICR-CD1 female mice were subjected to either six repeated injections of reserpine, to cause reserpine-induced myalgia (RIM6), or acidified saline intramuscular injections (ASI). In these two models, we evaluated the effect of BD1063 and pregabalin on thermal hypersensitivity, anxiety-like and depression-like behaviors, and on spinal cord gliosis. BD1063 exerted an antinociceptive effect on both reflexive (thermal hyperalgesia) and nonreflexive (anxiety- and depression-like) pain behaviors, and reduced spinal astroglial and microglial reactivity, following repeated treatment for 2 weeks. Interestingly, the effects of BD1063 were long-term, lasting several weeks after treatment discontinuation in both fibromyalgia-like models. Similar results were obtained with pregabalin, but the effects on pain behaviors lasted for a shorter length of time, and pregabalin did not significantly modulate spinal glial reactivity. The inhibitory and long-lasting effect of pharmacological blockade of σ1Rs on both sensory and affective dimensions of nociplastic-like pain and spinal cord gliosis in two experimental models of fibromyalgia support the application of this therapeutic strategy to treat fibromyalgia.
Identifiants
pubmed: 36233233
pii: ijms231911933
doi: 10.3390/ijms231911933
pmc: PMC9569697
pii:
doi:
Substances chimiques
Analgesics
0
Receptors, sigma
0
Pregabalin
55JG375S6M
Reserpine
8B1QWR724A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University of Girona
ID : MPCUdG2016/087
Organisme : Esteve (Spain)
ID : 011/18 17/01/2018
Références
Pain. 2008 Nov 30;140(2):292-304
pubmed: 18834667
Pain Manag. 2016 May;6(4):371-81
pubmed: 27296699
J Neurosci. 2018 Jul 11;38(28):6340-6349
pubmed: 29941444
Mol Neurobiol. 2021 Dec;58(12):6625-6646
pubmed: 34601668
Biochem Biophys Res Commun. 2017 Apr 1;485(2):301-306
pubmed: 28223219
Int J Mol Sci. 2020 Nov 11;21(22):
pubmed: 33187309
Eur J Pharmacol. 2018 May 15;827:117-124
pubmed: 29530591
Invest Ophthalmol Vis Sci. 2021 Jun 1;62(7):5
pubmed: 34086045
Front Pharmacol. 2019 Mar 22;10:222
pubmed: 30967775
Neuropeptides. 2021 Feb;85:102094
pubmed: 33171335
J Neurosci Res. 2017 Jun;95(6):1319-1329
pubmed: 27376880
Front Cell Neurosci. 2013 Apr 19;7:49
pubmed: 23626522
Cell Mol Life Sci. 2019 May;76(10):1889-1899
pubmed: 30788514
J Physiol. 2010 Jan 1;588(Pt 1):117-24
pubmed: 19933757
Naunyn Schmiedebergs Arch Pharmacol. 2019 Jul;392(7):801-812
pubmed: 30798370
Front Pharmacol. 2019 Jun 12;10:613
pubmed: 31263413
Trends Cell Biol. 2009 Feb;19(2):81-8
pubmed: 19144519
Cell Signal. 2017 Dec;40:116-124
pubmed: 28923416
Clin Pharmacokinet. 2010 Oct;49(10):661-9
pubmed: 20818832
Neuron. 2020 Sep 9;107(5):909-923.e6
pubmed: 32649865
Glia. 2009 May;57(7):744-54
pubmed: 19031439
Mediators Inflamm. 2015;2015:265056
pubmed: 26696751
Molecules. 2021 Apr 20;26(8):
pubmed: 33924258
Neurosci Lett. 1987 Apr 23;76(1):63-8
pubmed: 3035432
Neuroscience. 2021 Dec 15;479:125-139
pubmed: 34673142
Learn Mem. 2013 Mar 15;20(4):183-93
pubmed: 23504516
Methods Mol Biol. 2019;2034:13-26
pubmed: 31392674
Neurosci Lett. 2018 Apr 3;671:7-12
pubmed: 29410218
Toxicon. 2014 Apr;81:37-42
pubmed: 24491352
Eur J Pharmacol. 2015 Apr 15;753:51-65
pubmed: 25460020
Br J Pharmacol. 2019 Oct;176(20):3939-3955
pubmed: 31332781
Trends Pharmacol Sci. 2010 Dec;31(12):557-66
pubmed: 20869780
Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17537-42
pubmed: 17088553
Neurotherapeutics. 2020 Jul;17(3):846-860
pubmed: 32820378
J Neurophysiol. 2000 Apr;83(4):2239-59
pubmed: 10758132
Front Pharmacol. 2019 Jun 12;10:634
pubmed: 31249525
Pain. 2019 Jun;160(6):1383-1401
pubmed: 30720581
Pain. 2009 Nov;146(1-2):26-33
pubmed: 19646816
J Neurochem. 2010 Apr;113(2):552-61
pubmed: 20132471
Curr Pain Headache Rep. 2016 Apr;20(4):25
pubmed: 26922414
Int J Mol Sci. 2021 Oct 29;22(21):
pubmed: 34769165
Clin Exp Rheumatol. 2020 Jan-Feb;38 Suppl 123(1):3-8
pubmed: 32116216
Glia. 2020 Jul;68(7):1421-1434
pubmed: 32036619
Front Neurosci. 2019 Jul 16;13:733
pubmed: 31379486
PLoS One. 2022 Jul 12;17(7):e0271295
pubmed: 35819957
Br J Pharmacol. 2008 Jul;154(5):1125-34
pubmed: 18493253
Nat Neurosci. 2019 Oct;22(10):1649-1658
pubmed: 31451801
J Comp Neurol. 2015 Nov 1;523(16):2426-56
pubmed: 25940654
J Food Sci. 2020 Nov;85(11):3700-3710
pubmed: 33047814
AACN Clin Issues. 2005 Jul-Sep;16(3):277-90; quiz 413-5
pubmed: 16082231
Pharmacol Res. 2015 Oct;100:353-64
pubmed: 26316425
Psychopharmacology (Berl). 2014 Oct;231(19):3855-69
pubmed: 24639046
Pain. 2015 Mar;156(3):415-427
pubmed: 25599239
Purinergic Signal. 2022 Mar;18(1):83-92
pubmed: 34799827
Sci Rep. 2017 Oct 18;7(1):13428
pubmed: 29044171
J Med Chem. 2021 Jan 14;64(1):890-904
pubmed: 33372782
Eur J Pain. 2016 Mar;20(3):341-52
pubmed: 25913854
Sci Rep. 2017 Apr 25;7:46663
pubmed: 28440280
J Neurosci. 2001 Mar 15;21(6):2159-65
pubmed: 11245700
Neuropharmacology. 2016 Dec;111:34-46
pubmed: 27567941
Brain Res Bull. 2015 Oct;119(Pt A):93-100
pubmed: 26434709
J Neuroinflammation. 2015 Feb 17;12:29
pubmed: 25889537
Glia. 2012 Dec;60(12):2050-64
pubmed: 23002008
Scand J Pain. 2019 Dec 18;20(1):33-37
pubmed: 31730538
ACS Pharmacol Transl Sci. 2022 Mar 17;5(4):240-254
pubmed: 35434530
Brain Res Bull. 2022 Jan;178:69-81
pubmed: 34813897
Gene Ther. 2022 Feb;29(1-2):1-15
pubmed: 32424233
Pain Res Treat. 2016;2016:3191638
pubmed: 27069683
Neuropharmacology. 2019 May 1;149:169-180
pubmed: 30797030
Pain. 2015 Oct;156(10):2061-2071
pubmed: 26101837
Eur J Pharmacol. 1995 Jul 14;280(3):301-10
pubmed: 8566098
Muscle Nerve. 2001 Jan;24(1):37-46
pubmed: 11150964
J Pharmacol Exp Ther. 2011 Oct;339(1):161-72
pubmed: 21715561
Pain. 1983 Jun;16(2):109-110
pubmed: 6877845
Clin Rev Allergy Immunol. 2015 Oct;49(2):100-51
pubmed: 26445775
Behav Brain Res. 2012 Jan 1;226(1):242-9
pubmed: 21945299
Cell Calcium. 2009 Oct;46(4):282-92
pubmed: 19796812
Cell Rep. 2021 Nov 2;37(5):109936
pubmed: 34731609
Invest Ophthalmol Vis Sci. 2014 May 08;55(6):3375-84
pubmed: 24812552
Acta Physiol Hung. 1996;84(4):461-3
pubmed: 9328632
Pain Rep. 2021 Mar 09;6(1):e864
pubmed: 33981920
Pharmacol Res. 2021 Jan;163:105339
pubmed: 33276102
Biophys J. 2010 Apr 7;98(7):1182-91
pubmed: 20371317
Physiol Rev. 2011 Apr;91(2):461-553
pubmed: 21527731
J Neurochem. 2014 May;129(3):484-94
pubmed: 24384038
Front Pharmacol. 2019 Apr 24;10:419
pubmed: 31068816
Ann Rheum Dis. 2017 Feb;76(2):318-328
pubmed: 27377815
Exp Brain Res. 2021 May;239(5):1451-1463
pubmed: 33677656
Pain. 1988 Jan;32(1):77-88
pubmed: 3340425
Eur J Pain. 2016 Apr;20(4):594-606
pubmed: 26358747
Nat Rev Neurosci. 2010 Dec;11(12):823-36
pubmed: 21068766
Handb Exp Pharmacol. 2017;244:131-161
pubmed: 28275913
Semin Arthritis Rheum. 2021 Feb;51(1):166-174
pubmed: 33383293
J Neurophysiol. 1994 May;71(5):1646-60
pubmed: 8064340
J Clin Med. 2022 Apr 22;11(9):
pubmed: 35566476
J Neuroinflammation. 2022 Sep 21;19(1):231
pubmed: 36131309
Biol Pharm Bull. 2015;38(9):1320-7
pubmed: 26328487
Naunyn Schmiedebergs Arch Pharmacol. 2014 Oct;387(10):935-42
pubmed: 24958161
Antioxid Redox Signal. 2015 Apr 1;22(10):799-818
pubmed: 25557043
Br J Anaesth. 2019 Aug;123(2):e215-e225
pubmed: 31030988
Front Behav Neurosci. 2017 Feb 21;11:31
pubmed: 28270756
FASEB J. 2020 Apr;34(4):5951-5966
pubmed: 32157739
Br J Pharmacol. 2014 Dec;171(24):5881-97
pubmed: 25158784
Adv Pharmacol. 2016;75:179-215
pubmed: 26920013
Vet Rec. 1985 Apr 20;116(16):431-6
pubmed: 3923690
J Pain. 2009 Dec;10(12):1231-41
pubmed: 19592308
Exp Neurol. 2020 Nov;333:113434
pubmed: 32795464
Biomed Pharmacother. 2021 Dec;144:112272
pubmed: 34607109
J Pharmacol Exp Ther. 2008 Nov;327(2):491-502
pubmed: 18723775
Biochem Pharmacol. 2019 Oct;168:119-132
pubmed: 31254493
Expert Opin Pharmacother. 2015 Jun;16(9):1347-68
pubmed: 26001183
Pain Res Treat. 2012;2012:817347
pubmed: 22191025
J Comp Neurol. 1995 Mar 20;353(4):480-505
pubmed: 7759612
Arch Int Pharmacodyn Ther. 1977 Oct;229(2):327-36
pubmed: 596982
Sci Rep. 2016 Apr 18;6:24591
pubmed: 27087602
J Pain. 2012 Nov;13(11):1107-21
pubmed: 23063344
Cell. 2007 Nov 2;131(3):596-610
pubmed: 17981125
Neuropharmacology. 2010 Nov;59(6):460-7
pubmed: 20600171
Cell Death Dis. 2021 Dec 14;12(12):1159
pubmed: 34907173
Neuroscience. 2000;97(1):155-70
pubmed: 10771347
Mol Cell Neurosci. 2015 Jan;64:104-15
pubmed: 25497271
Brain. 2022 Mar 29;145(1):154-167
pubmed: 34373893
Cochrane Database Syst Rev. 2018 Feb 19;2:CD010585
pubmed: 29457627
Brain Res Bull. 1992 May;28(5):679-82
pubmed: 1377586
Neuron Glia Biol. 2011 Feb;7(1):41-6
pubmed: 22166726
Toxicon. 2021 May;195:104-110
pubmed: 33753115
Exp Physiol. 2002 Mar;87(2):251-8
pubmed: 11856971
Neuroscience. 2018 Feb 21;372:181-191
pubmed: 29289721
Neuropharmacology. 2007 Dec;53(7):842-53
pubmed: 17889907
Pain. 2009 Oct;145(3):294-303
pubmed: 19505761
Biochem Soc Trans. 2010 Apr;38(2):525-8
pubmed: 20298215
J Physiol. 2019 Apr;597(7):2097-2113
pubmed: 30719699
Neuroscience. 2021 Jun 15;465:46-59
pubmed: 33945796
Pain Physician. 2020 Nov;23(6):E581-E590
pubmed: 33185377
J Neurochem. 2015 Sep;134(5):904-14
pubmed: 26031312
Neural Regen Res. 2022 Feb;17(2):450-458
pubmed: 34269222
Pain. 2004 Jul;110(1-2):149-57
pubmed: 15275762
Sci Rep. 2018 Mar 1;8(1):3873
pubmed: 29497125
Neuropharmacology. 2014 Nov;86:57-66
pubmed: 24929111
Brain. 2014 Jul;137(Pt 7):1998-2014
pubmed: 24755275
Brain Struct Funct. 2016 Jan;221(1):535-61
pubmed: 25403254
Pain. 2009 Jun;143(3):252-261
pubmed: 19375855
Cell Rep. 2019 Dec 17;29(12):3847-3858.e5
pubmed: 31851918
Sci Rep. 2022 Jun 12;12(1):9719
pubmed: 35691979
Neurosci Res. 2022 Aug;181:87-94
pubmed: 35304863
Neurochem Int. 2020 Mar;134:104673
pubmed: 31926196
Brain Res. 1985 May 20;334(2):243-54
pubmed: 2986783
Int J Mol Sci. 2020 Oct 23;21(21):
pubmed: 33114203