Lymphocyte Count and Neutrophil-to-Lymphocyte Ratio Are Associated with Mild Cognitive Impairment in Parkinson's Disease: A Single-Center Longitudinal Study.

Parkinson’s disease cognitive impairment lymphocyte count neutrophil-to-lymphocyte ratio peripheral immune system

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
22 Sep 2022
Historique:
received: 02 08 2022
revised: 13 09 2022
accepted: 20 09 2022
entrez: 14 10 2022
pubmed: 15 10 2022
medline: 15 10 2022
Statut: epublish

Résumé

Lymphocyte count and neutrophil-to-lymphocyte ratio (NLR) may represent useful biomarkers of Parkinson's disease (PD), but their role in PD-related mild cognitive impairment (MCI) has not been fully elucidated. The present study aimed to confirm whether these immunological measures can discriminate PD patients from healthy controls (HC) and establish their feasibility as prognostic biomarkers of MCI in PD. Immunological data at baseline were analyzed in 58 drug-naïve PD patients and 58 HC matched 1:1 for age, sex, and cardiovascular comorbidities. We selected a subgroup of 51 patients from this initial cohort who underwent longitudinal neuropsychological assessments through the Addenbrooke's Cognitive Examination Revised (ACE-R) test. We considered the last examination available to analyze the relationship between ACE-R test scores and immunological measures. We found that lymphocyte count was lower and NLR higher in PD than HC (

Identifiants

pubmed: 36233411
pii: jcm11195543
doi: 10.3390/jcm11195543
pmc: PMC9571051
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : University of Piemomte Orientale
ID : Aging Project

Références

Neurol Sci. 2019 Sep;40(9):1877-1885
pubmed: 31069585
Sci Rep. 2016 Sep 22;6:33738
pubmed: 27652978
Neuroscience. 2019 Apr 1;403:70-78
pubmed: 29126955
Front Neurol. 2021 Jul 01;12:693318
pubmed: 34276542
Front Immunol. 2017 Mar 02;8:211
pubmed: 28303140
J Transl Med. 2021 Sep 6;19(1):378
pubmed: 34488776
Expert Rev Cardiovasc Ther. 2016;14(5):573-7
pubmed: 26878164
Parkinsonism Relat Disord. 2018 Jan;46 Suppl 1:S30-S33
pubmed: 28780180
Brain Behav Immun. 2020 Oct;89:668-674
pubmed: 32688028
J Neuroinflammation. 2018 Jul 12;15(1):205
pubmed: 30001736
J Neuroinflammation. 2020 Mar 14;17(1):84
pubmed: 32171317
Breast Cancer Res. 2017 Jan 5;19(1):2
pubmed: 28057046
J Thorac Oncol. 2010 Sep;5(9):1315-6
pubmed: 20736804
Neurol Sci. 2017 Feb;38(2):287-293
pubmed: 27837368
Brain Behav Immun. 2021 Nov;98:110-121
pubmed: 34403737
J Neurol Neurosurg Psychiatry. 2018 Apr;89(4):339-345
pubmed: 29248892
Front Aging Neurosci. 2019 Dec 05;11:332
pubmed: 31866854
Parkinsonism Relat Disord. 2016 Dec;33:12-26
pubmed: 27765426
Parkinsons Dis. 2015;2015:579417
pubmed: 26351616
Neurol Sci. 2016 Mar;37(3):385-92
pubmed: 26563847
Curr Alzheimer Res. 2019;16(14):1309-1315
pubmed: 31902361
J Clin Invest. 2009 Jan;119(1):182-92
pubmed: 19104149
Mov Disord. 2021 Dec;36(12):2969-2971
pubmed: 34647353
Psychogeriatrics. 2017 Nov;17(6):506-508
pubmed: 28386987
Mov Disord. 2008 Nov 15;23(15):2129-70
pubmed: 19025984
Clinics (Sao Paulo). 2020 Apr 17;75:e1450
pubmed: 32321113
Mov Disord. 2015 Oct;30(12):1591-601
pubmed: 26474316
Front Immunol. 2018 Jan 11;8:1974
pubmed: 29375582
J Neurol Neurosurg Psychiatry. 2008 Apr;79(4):368-76
pubmed: 18344392
Mov Disord. 2012 Aug;27(9):1173-7
pubmed: 22733390
J Vasc Surg. 2014 Mar;59(3):768-73
pubmed: 24571940
Mov Disord. 2021 Oct;36(10):2426-2430
pubmed: 34101890
Neurol Sci. 2015 Mar;36(3):423-8
pubmed: 25288159
J Biol Regul Homeost Agents. 2018 May-Jun;32(3):687-691
pubmed: 29921400
Mov Disord. 2004 Sep;19(9):1020-8
pubmed: 15372591
Ann Neurol. 2021 Apr;89(4):803-812
pubmed: 33527442
J Neurol Neurosurg Psychiatry. 2019 Nov;90(11):1234-1243
pubmed: 31444276
Eur J Neurol. 2009 Jan;16(1):142-7
pubmed: 19049504
Mov Disord. 2012 Mar;27(3):349-56
pubmed: 22275317
Front Neurol. 2019 Mar 19;10:232
pubmed: 30941089

Auteurs

Elena Contaldi (E)

Movement Disorders Centre, Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy.
PhD Program in Medical Sciences and Biotechnology, University of Piemonte Orientale, 28100 Novara, Italy.

Luca Magistrelli (L)

Movement Disorders Centre, Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy.
PhD Program in Clinical and Experimental Medicine and Medical Humanities, University of Insubria, 21100 Varese, Italy.

Marco Cosentino (M)

Center of Research in Medical Pharmacology, University of Insubria, 21100 Varese, Italy.
Center for Research in Neuroscience, University of Insubria, 21100 Varese, Italy.

Franca Marino (F)

Center of Research in Medical Pharmacology, University of Insubria, 21100 Varese, Italy.
Center for Research in Neuroscience, University of Insubria, 21100 Varese, Italy.

Cristoforo Comi (C)

Center of Research in Medical Pharmacology, University of Insubria, 21100 Varese, Italy.
Department of Translational Medicine, Neurology Unit, S. Andrea Hospital, University of Piemonte Orientale, 13100 Vercelli, Italy.

Classifications MeSH