Moco Carrier and Binding Proteins.
Moco
molybdenum cofactor
molybdenum cofactor binding protein
molybdenum cofactor carrier protein
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
04 Oct 2022
04 Oct 2022
Historique:
received:
31
08
2022
revised:
25
09
2022
accepted:
26
09
2022
entrez:
14
10
2022
pubmed:
15
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
The molybdenum cofactor (Moco) is the active site prosthetic group found in numerous vitally important enzymes (Mo-enzymes), which predominantly catalyze 2 electron transfer reactions. Moco is synthesized by an evolutionary old and highly conserved multi-step pathway, whereby the metal insertion reaction is the ultimate reaction step here. Moco and its intermediates are highly sensitive towards oxidative damage and considering this, they are believed to be permanently protein bound during synthesis and also after Moco maturation. In plants, a cellular Moco transfer and storage system was identified, which comprises proteins that are capable of Moco binding and release but do not possess a Moco-dependent enzymatic activity. The first protein described that exhibited these properties was the Moco carrier protein (MCP) from the green alga
Identifiants
pubmed: 36235107
pii: molecules27196571
doi: 10.3390/molecules27196571
pmc: PMC9571131
pii:
doi:
Substances chimiques
Carrier Proteins
0
Coenzymes
0
Metalloproteins
0
Molybdenum Cofactors
0
Molybdenum
81AH48963U
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK 2223/1
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