Predictive Value of the Advanced Lipoprotein Profile and Glycated Proteins on Diabetic Retinopathy.
diabetic retinopathy
glycoproteins
lipoproteins
nuclear magnetic resonance spectroscopy
remnants
triglycerides
type 1 diabetes
type 2 diabetes
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
22 Sep 2022
22 Sep 2022
Historique:
received:
16
08
2022
revised:
08
09
2022
accepted:
16
09
2022
entrez:
14
10
2022
pubmed:
15
10
2022
medline:
18
10
2022
Statut:
epublish
Résumé
This study aimed to assess whether the advanced characteristics of serum lipoprotein subclasses could better predict the risk of developing diabetic retinopathy (DR) and its severity compared to other established risk factors in subjects with type 1 (T1D) and type 2 (T2D) diabetes. This observational, cross-sectional substudy analyzed DR-related data from 309 T1D and 264 T2D subjects. The advanced lipoprotein and glycoprotein profile was determined by nuclear magnetic resonance (NMR) spectroscopy (Liposcale test). NMR analysis of lipoproteins revealed that T1D subjects with DR showed standard non-HDL particles, despite higher IDL lipid concentrations. Notably, IDL lipids were elevated in T1D subjects with worsened DR. VLDL and LDL were smaller, whereas HDL triglycerides were increased in DR compared with non-DR. On the other hand, the T2D subjects with DR showed altered characteristics in the LDL fraction, mainly revealed by a significant decrease in smaller LDL and a reduction in LDL-C. Moreover, the glycoprotein profile did not reveal significant changes among DR groups, regardless of the type of diabetes. However, lipoprotein characteristics and glycoproteins unveiled by NMR analysis did not improve the predictive value of conventional lipids or other traditional, well-established biomarkers of DR in our cohorts.
Identifiants
pubmed: 36235586
pii: nu14193932
doi: 10.3390/nu14193932
pmc: PMC9572733
pii:
doi:
Substances chimiques
Cholesterol, LDL
0
Glycoproteins
0
Lipoproteins
0
Lipoproteins, LDL
0
Lipoproteins, VLDL
0
Triglycerides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI15/0625
Organisme : Instituto de Salud Carlos III
ID : PI17/01362
Organisme : Instituto de Salud Carlos III
ID : PI17/00232
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