Abnormalities in the migration of neural precursor cells in familial bipolar disorder.
Bipolar disorder
Brain structure
Cell migration
EGF/ERBB signaling
Genetics
Mean-squared displacement
Journal
Disease models & mechanisms
ISSN: 1754-8411
Titre abrégé: Dis Model Mech
Pays: England
ID NLM: 101483332
Informations de publication
Date de publication:
01 10 2022
01 10 2022
Historique:
received:
22
02
2022
accepted:
20
09
2022
pubmed:
15
10
2022
medline:
20
10
2022
entrez:
14
10
2022
Statut:
ppublish
Résumé
Cellular migration is a ubiquitous feature that brings brain cells into appropriate spatial relationships over time; and it helps in the formation of a functional brain. We studied the migration patterns of induced pluripotent stem cell-derived neural precursor cells (NPCs) from individuals with familial bipolar disorder (BD) in comparison with healthy controls. The BD patients also had morphological brain abnormalities evident on magnetic resonance imaging. Time-lapse analysis of migrating cells was performed, through which we were able to identify several parameters that were abnormal in cellular migration, including the speed and directionality of NPCs. We also performed transcriptomic analysis to probe the mechanisms behind the aberrant cellular phenotype identified. Our analysis showed the downregulation of a network of genes, centering on EGF/ERBB proteins. The present findings indicate that collective, systemic dysregulation may produce the aberrant cellular phenotype, which could contribute to the functional and structural changes in the brain reported for bipolar disorder. This article has an associated First Person interview with the first author of the paper.
Identifiants
pubmed: 36239094
pii: 277960
doi: 10.1242/dmm.049526
pmc: PMC9612872
pii:
doi:
Substances chimiques
Epidermal Growth Factor
62229-50-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : DBT-Wellcome Trust India Alliance
ID : IA/CPHI/20/1/505266
Pays : India
Informations de copyright
© 2022. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interests The authors declare no competing or financial interests.
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