Total Intravenous Anesthesia Versus Inhaled Sevoflurane in Obstructive Sleep Apnea Surgery: A Randomized Controlled Trial.

hypoglossal nerve stimulation inhalational anesthesia obstructive sleep apnea recovery time total intravenous anesthesia

Journal

The Laryngoscope
ISSN: 1531-4995
Titre abrégé: Laryngoscope
Pays: United States
ID NLM: 8607378

Informations de publication

Date de publication:
04 2023
Historique:
revised: 23 09 2022
received: 02 06 2022
accepted: 24 09 2022
pubmed: 15 10 2022
medline: 17 3 2023
entrez: 14 10 2022
Statut: ppublish

Résumé

Specific guidelines regarding an optimal general anesthesia (GA) approach to obstructive sleep apnea (OSA) patients remain undefined. Literature comparing the efficacy of total intravenous anesthesia (TIVA) and inhalational anesthesia in this population is sparse. We hypothesize that OSA patients receiving TIVA will experience reduced recovery times and other improved post-surgical outcomes. Randomized controlled trial. Adult OSA patients undergoing upper airway surgery (hypoglossal nerve stimulation [HNS], nasal, or palate surgery) from February 2020-December 2020 were included. A post-anesthesia care unit (PACU) nursing survey documented patients' alertness, pain, oxygen supplementation, and postoperative nausea and vomiting from PACU arrival to 2 hours. Perioperative timepoints from the electronic medical record (EMR) and a nurse-estimated Phase I recovery time were collected. One hundred eleven patients were included (46 TIVA and 65 inhalational anesthesia). Per EMR-recorded timepoints, TIVA patients undergoing HNS and palate surgery experienced Phase I Time reductions of 12.5 min (p = 0.042) and 27.5 min (p = 0.016), respectively. Per the PACU survey, TIVA patients undergoing any surgery, HNS, or palate surgery experienced nurse-estimated Phase I Time reductions of 16.5 min (p = 0.004), 12.5 min (p = 0.031), and 38.5 min (p = 0.024), respectively. Overall, TIVA patients experienced higher alertness and pain ratings, and lower oxygen supplementation requirements from PACU arrival to 30 min (p < 0.05). Patients with OSA receiving TIVA for GA maintenance during upper airway procedures experienced reduced recovery times and oxygen supplementation requirements, and a more rapid return to alertness. Future work toward developing optimized anesthetic guidelines for OSA patients is merited. 3 Laryngoscope, 133:984-992, 2023.

Identifiants

pubmed: 36239660
doi: 10.1002/lary.30438
doi:

Substances chimiques

Sevoflurane 38LVP0K73A
Propofol YI7VU623SF
Anesthetics, Intravenous 0
Anesthetics, Inhalation 0

Types de publication

Randomized Controlled Trial Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

984-992

Informations de copyright

© 2022 The American Laryngological, Rhinological and Otological Society, Inc.

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Auteurs

Leonard E Estephan (LE)

Department of Otolaryngology - Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

Sarah Sussman (S)

Department of Otolaryngology - Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

Matthew Stewart (M)

Department of Otolaryngology - Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

Tingting Zhan (T)

Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Adam Thaler (A)

Department of Anesthesiology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

Maurits Boon (M)

Department of Otolaryngology - Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

Patrick Hunt (P)

Department of Anesthesiology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

Colin Huntley (C)

Department of Otolaryngology - Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.

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