The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
revised:
29
07
2022
received:
09
06
2022
accepted:
14
08
2022
pubmed:
15
10
2022
medline:
27
1
2023
entrez:
14
10
2022
Statut:
ppublish
Résumé
This study explored the impact of time-restricted eating (TRE) versus standard dietary advice (SDA) on bone health. Adults with ≥1 component of metabolic syndrome were randomized to TRE (ad libitum eating within 12 hours) or SDA (food pyramid brochure). Bone turnover markers and bone mineral content/density by dual energy x-ray absorptiometry were assessed at baseline and 6-month follow-up. Statistical analyses were performed in the total population and by weight loss response. In the total population (n = 42, 76% women, median age 47 years [IQR: 31-52]), there were no between-group differences (TRE vs. SDA) in any bone parameter. Among weight loss responders (≥0.6 kg weight loss), the bone resorption marker β-carboxyterminal telopeptide of type I collagen tended to decrease after TRE but increase after SDA (between-group differences p = 0.041), whereas changes in the bone formation marker procollagen type I N-propeptide did not differ between groups. Total body bone mineral content decreased after SDA (p = 0.028) but remained unchanged after TRE (p = 0.31) in weight loss responders (between-group differences p = 0.028). Among nonresponders (<0.6 kg weight loss), there were no between-group differences in bone outcomes. TRE had no detrimental impact on bone health, whereas, when weight loss occurred, it was associated with some bone-sparing effects compared with SDA.
Identifiants
pubmed: 36239695
doi: 10.1002/oby.23577
pmc: PMC10092311
doi:
Substances chimiques
Procollagen Type I
0
Types de publication
Randomized Controlled Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
85-95Informations de copyright
© 2022 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
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