Contribution of Common Genetic Variants to Risk of Early Onset Ischemic Stroke.
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
31 Aug 2022
31 Aug 2022
Historique:
received:
05
10
2021
accepted:
09
06
2022
entrez:
14
10
2022
pubmed:
15
10
2022
medline:
15
10
2022
Statut:
aheadofprint
Résumé
Current genome-wide association studies of ischemic stroke have focused primarily on late onset disease. As a complement to these studies, we sought to identifythe contribution of common genetic variants to risk of early onset ischemic stroke. We performed a meta-analysis of genome-wide association studies of early onset stroke (EOS), ages 18-59, using individual level data or summary statistics in 16,730 cases and 599,237 non-stroke controls obtained across 48 different studies. We further compared effect sizes at associated loci between EOS and late onset stroke (LOS) and compared polygenic risk scores for venous thromboembolism between EOS and LOS. We observed genome-wide significant associations of EOS with two variants in The
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
Current genome-wide association studies of ischemic stroke have focused primarily on late onset disease. As a complement to these studies, we sought to identifythe contribution of common genetic variants to risk of early onset ischemic stroke.
METHODS
METHODS
We performed a meta-analysis of genome-wide association studies of early onset stroke (EOS), ages 18-59, using individual level data or summary statistics in 16,730 cases and 599,237 non-stroke controls obtained across 48 different studies. We further compared effect sizes at associated loci between EOS and late onset stroke (LOS) and compared polygenic risk scores for venous thromboembolism between EOS and LOS.
RESULTS
RESULTS
We observed genome-wide significant associations of EOS with two variants in
DISCUSSION
CONCLUSIONS
The
Identifiants
pubmed: 36240095
pii: WNL.0000000000201006
doi: 10.1212/WNL.0000000000201006
pmc: PMC9620803
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
ID : 212946/Z/18/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12026/2
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P30 AG028747
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100178
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00017/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U137686851
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS114045
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL088521
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_14135
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL135129
Pays : United States
Organisme : Medical Research Council
ID : MR/S004130/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_13049
Pays : United Kingdom
Informations de copyright
© 2022 American Academy of Neurology.
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