Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection.

Mice Animals Gastrointestinal Microbiome / physiology Nociceptors / physiology Substance P Dysbiosis Inflammatory Bowel Diseases Inflammation
IBD TRPV1(+) nociceptor intestinal damage and inflammation intestinal microbiota neuron-microbiota crosstalk substance P tissue protection

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
27 10 2022
Historique:
received: 27 05 2021
revised: 14 07 2022
accepted: 29 08 2022
pubmed: 15 10 2022
medline: 2 11 2022
entrez: 14 10 2022
Statut: ppublish

Résumé

Nociceptive pain is a hallmark of many chronic inflammatory conditions including inflammatory bowel diseases (IBDs); however, whether pain-sensing neurons influence intestinal inflammation remains poorly defined. Employing chemogenetic silencing, adenoviral-mediated colon-specific silencing, and pharmacological ablation of TRPV1

Identifiants

DOI: 10.1016/j.cell.2022.09.008 PMID: 36240781 PMC: PMC9617796
pubmed: 36240781
pii: S0092-8674(22)01130-8
doi: 10.1016/j.cell.2022.09.008
pmc: PMC9617796
mid: NIHMS1834595
pii:
doi:

Substances chimiques

Substance P 33507-63-0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4170-4189.e20

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR077007
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR070116
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI095466
Pays : United States
Organisme : NIMH NIH HHS
ID : K08 MH130773
Pays : United States
Organisme : NIAID NIH HHS
ID : DP2 AI154440
Pays : United States
Organisme : NICHD NIH HHS
ID : DP2 HD101401
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA027065
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK132244
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK126871
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI151599
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK128308
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI095608
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR077183
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103901
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI172027
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests D.A. has contributed to scientific advisory boards at Pfizer, Takeda, and the KRF.

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Auteurs

Wen Zhang (W)

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.

Mengze Lyu (M)

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.

Nicholas J Bessman (NJ)

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.

Zili Xie (Z)

Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO, USA.

Mohammad Arifuzzaman (M)

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.

Hiroshi Yano (H)

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.

Christopher N Parkhurst (CN)

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.

Coco Chu (C)

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.

Lei Zhou (L)

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.

Gregory G Putzel (GG)

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.

Ting-Ting Li (TT)

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.

Wen-Bing Jin (WB)

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.

Jordan Zhou (J)

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.

Hongzhen Hu (H)

Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO, USA.

Amy M Tsou (AM)

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Friedman Center for Nutrition and Inflammation, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Weill Cornell Medical College, New York, NY, USA.

Chun-Jun Guo (CJ)

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Friedman Center for Nutrition and Inflammation, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.

David Artis (D)

Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Friedman Center for Nutrition and Inflammation, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA. Electronic address: dartis@med.cornell.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Gut-innervating nociceptors regulate the...
questionsmedicales.fr › Eucaryotes › Animaux › Gut-innervating nociceptors regulate the...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Gut-innervating nociceptors regulate the...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Nocicepteurs › Gut-innervating nociceptors regulate the...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Kinines › Tachykinines › Substance P › Gut-innervating nociceptors regulate the...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Dysbiose › Gut-innervating nociceptors regulate the...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Gut-innervating nociceptors regulate the...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Gut-innervating nociceptors regulate the...