Effect of endoscopic sleeve gastroplasty on gastric emptying, motility and hormones: a comparative prospective study.
gastric emptying
obesity
Journal
Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
08
05
2022
accepted:
30
09
2022
medline:
8
5
2023
pubmed:
15
10
2022
entrez:
14
10
2022
Statut:
ppublish
Résumé
Endoscopic sleeve gastroplasty (ESG) has gained global adoption but our understanding of its mechanism(s) of action and durability of efficacy is limited. We sought to determine changes in gastric emptying (GE), gastric motility (GM), hormones and eating behaviours after ESG. A priori 36 (ESG=18; LS=18) participated in this substudy. Baseline characteristics were similar between the two groups. At 3 months, T ESG promotes weight loss through several key mechanistic pathways involving GE and hormones while preserving GM. These findings further support clinical adoption of this technique for the management of obesity. NCT03406975.
Identifiants
pubmed: 36241388
pii: gutjnl-2022-327816
doi: 10.1136/gutjnl-2022-327816
pmc: PMC10102256
mid: NIHMS1877235
doi:
Substances chimiques
Ghrelin
0
Banques de données
ClinicalTrials.gov
['NCT03406975']
Types de publication
Randomized Controlled Trial
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1073-1080Subventions
Organisme : NIDDK NIH HHS
ID : P01 DK068055
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002377
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: ACS: research grant support from Apollo Endosurgery, Boston Scientific, Endogenex, Endo-TAGSS and Enterasense. Consultant for Apollo Endosurgery, ERBE, GI Dynamics, Intuitive and Olympus; AA: stockholder in Gila Therapeutics, Phenomix Sciences; consultant fees from Rhythm Pharmaceuticals, General Mills; BKAD: consulting fee from Endogenex, Endo-TAGSS, Metamodix and BFKW; consulting fee and grant/research support from USGI, Cairn Diagnostics, Aspire Bariatrics and Boston Scientific; speaker honorarium from Olympus and Johnson and Johnson; speaker honorarium and grant/research support from Medtronic and EndoGastric Solutions; and research support/grant from Apollo Endosurgery and Spatz Medical; MC: advisor to Phenomics Sciences, holder of stock options.
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