Cuprizone feeding induces swollen astrocyte endfeet.
Aquaporin-4
Astrocytic endfeet
Cuprizone
Edema
Electron microscopy
Multiple sclerosis
Orthogonal arrays of particles (OAPs)
Journal
Pflugers Archiv : European journal of physiology
ISSN: 1432-2013
Titre abrégé: Pflugers Arch
Pays: Germany
ID NLM: 0154720
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
11
04
2022
accepted:
04
10
2022
revised:
29
09
2022
pubmed:
15
10
2022
medline:
18
11
2022
entrez:
14
10
2022
Statut:
ppublish
Résumé
The cuprizone model is a widely used model to study the pathogenesis of multiple sclerosis (MS). Due to the selective loss of mature oligodendrocytes and myelin, it is mainly being used to study demyelination and the mechanisms of remyelination, as well as the efficiency of compounds or therapeutics aiming at remyelination. Although early investigations using high dosages of cuprizone reported the occurrence of hydrocephalus, it has long been assumed that cuprizone feeding at lower dosages does not induce changes at the blood-brain barrier (BBB). Here, by analyzing BBB ultrastructure with high-resolution electron microscopy, we report changes at astrocytic endfeet surrounding vessels in the brain parenchyma. Particularly, edema formation around blood vessels and swollen astrocytic endfeet already occurred after feeding low dosages of cuprizone. These findings indicate changes in BBB function that will have an impact on the milieu of the central nervous system (CNS) in the cuprizone model and need to be considered when studying the mechanisms of de- and remyelination.
Identifiants
pubmed: 36241864
doi: 10.1007/s00424-022-02759-8
pii: 10.1007/s00424-022-02759-8
pmc: PMC9663402
doi:
Substances chimiques
Cuprizone
5N16U7E0AO
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1275-1283Informations de copyright
© 2022. The Author(s).
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