Glycaemic variability and progression of chronic kidney disease in people with diabetes and comorbid kidney disease: Retrospective cohort study.
Chronic kidney disease
Diabetes nephropathy
End-stage kidney disease
Glycaemic variability
HbA1c variability
Microvascular complication
Journal
Diabetes research and clinical practice
ISSN: 1872-8227
Titre abrégé: Diabetes Res Clin Pract
Pays: Ireland
ID NLM: 8508335
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
03
05
2022
revised:
15
08
2022
accepted:
06
10
2022
pubmed:
16
10
2022
medline:
26
11
2022
entrez:
15
10
2022
Statut:
ppublish
Résumé
To investigate the association between glycaemic variability and the development of End-Stage-Kidney-Disease (ESKD) among individuals with diabetes and chronic kidney disease. A cohort study using UK electronic primary care health records from the Clinical Practice Research Datalink. Glycaemic variability was assessed using a variability score and intra-individual coefficient of variation (CV) of HbA1c. We calculated sub-distribution hazard ratios (sHR) for developing ESKD using competing risk regression analysis. There were 37,222 eligible participants (45.5 % male), with a mean age of 76.4 years (SD ± 9.2), and a mean baseline eGFR 40.7 (±10.7) ml/min/1.73 m Glycaemic variability was strongly associated with the development of ESKD in people with diabetes and CKD.
Identifiants
pubmed: 36243232
pii: S0168-8227(22)00931-7
doi: 10.1016/j.diabres.2022.110117
pii:
doi:
Substances chimiques
Blood Glucose
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110117Informations de copyright
Crown Copyright © 2022. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.